65501-87-3

Basic information

• Product Name: Galangustin
• CAS NO: 65501-87-3
• Molecular Weight: 314.295
• Mol File: 65501-87-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Galangustin(CAS DataBase Reference)
• NIST Chemistry Reference: Galangustin(65501-87-3)
• EPA Substance Registry System: Galangustin(65501-87-3)

Safety Data

• Hazardous Substances Data: 65501-87-3(Hazardous Substances Data)

Upstream product

• 42996-84-9 p-methoxycinnamoyl chloride 
• 20032-42-2 2,5-dimethoxyresorcinol 
• 6274-74-4 2,6-dibenzyloxy-1,4-dimethoxybenzene 
• 42528-81-4 2,6-bis-benzyloxy-benzene-1,4-diol 
• 6625-45-2 2,6-bis-benzyloxy-[1,4]benzoquinone 
• 55020-64-9 1,2,3-tris-benzyloxybenzene 
• 87-66-1 2-hydroxyresorcinol 
• 794-94-5 p-Methoxybenzoic anhydride 
• 51876-19-8 5,7,8-trihydroxy-4'-methoxyflavone 

Downstream Products

• 67884-14-4 5,7-diacetoxy-8,4'-dimethoxyflavone 
• 57096-03-4 5-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4-benzopyrone 

Relevant articles and documents

Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity

Wogonin, a natural product isolated from the plant Scutellaria baicalensis, has been shown to be a potent and selective inhibitor of CDK9. With the purpose of investigating the activity and selectivity of this chemical scaffold, several series of wogonin derivatives were prepared and screened for CDK9 inhibition and cellular antiproliferative activity. Among these compounds, the drug-like compound 51 showed potent activity against CDK9 (IC50 = 19.9 nM) and MV4-11 cell growth (IC50 = 20 nM). In addition, compound 51 showed much improved physicochemical properties, such as water solubility, compared with the parent compound wogonin. The follow-up studies showed that the compound 51 is selective toward CDK9-overexpressing cancer cells over normal cells. Preliminary mechanism studies on the anticancer effect indicated that 51 inhibited the proliferation of MV4-11 cells via caspase-dependent apoptosis. In addition, highlighted compound 51 showed significant antitumor activity in mouse acute myeloid leukemia (AML) models without producing apparent toxic effects in vivo, which gave us a new tool for further investigation of CDK9-targeted inhibitor as a potential antitumor drug especially for AML.

O-methylation of flavonoids by cell-free extracts of calamondin orange

Cell-free extracts of calamondin orange (Citrus mitis) catalysed the O-methylation of almost all hydroxyls of a number of flavonoids, indicating the existence in citrus tissues of ortho, meta, para and 3-O-methyltransferases. The latter, hitherto unreported enzyme, catalysed the formation of 3-O-methyl ethers of galangin and quercetin. The stepwise O-methylation of a number of compounds, especially quercetin and quercetagetin, tends to suggest a coordinated sequence of O-methylations on the surface of a multienzyme complex. The methyl acceptor abilities of the flavonoid substrates used are discussed in relation to their hydroxyl substitution patterns and their negative electron density distribution.