6552-63-2

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE
• Synonyms: 4'-CHLORO-4-METHOXYCHALCONE;1-(4-CHLOROPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE
• CAS NO: 6552-63-2
• Molecular Formula: C₁₆H₁₃ClO₂
• Molecular Weight: 272.73
• Mol File: 6552-63-2.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 434.8 °C at 760 mmHg
• Flash Point: 176.1 °C
• Appearance: /
• Density: 1.207 g/cm³
• Vapor Pressure: 9.21E-08mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE(6552-63-2)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE(6552-63-2)

Safety Data

• Hazardous Substances Data: 6552-63-2(Hazardous Substances Data)

Usage

General Description

1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one is a chemical compound with the molecular formula C16H13ClO2. It is a yellow crystalline solid that is used in the synthesis of pharmaceuticals and other organic compounds. 1-(4-CHLOROPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE is a chalcone derivative, which means it has a central 1,3-diphenylpropenone scaffold with a chlorine atom on one phenyl ring and a methoxy group on the other. Chalcones have been studied for their potential anti-cancer, anti-inflammatory, and antimicrobial properties, and 1-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one may have similar biological activities. Its chemical structure and properties make it a valuable building block in organic synthesis and medicinal chemistry.

InChI:InChI=1/C16H13ClO2/c1-19-15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(17)8-6-13/h2-11H,1H3/b11-4+

Upstream product

• 58518-76-6 ((1-(4-chlorophenyl)vinyl)oxy)trimethylsilane 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 108-90-7 chlorobenzene 
• 42996-84-9 p-methoxycinnamoyl chloride 
• 104-46-1 anethole 
• 90956-78-8 2,3-dibromo-3-(4-methoxyphenyl)-1-(4-chlorophenyl)-propan-1-one 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 108325-94-6 (4-Chloro-phenyl)-[4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-methanone 
• 74007-47-9 1-(4-Chloro-phenyl)-3,3-dimethoxy-2-(4-methoxy-phenyl)-propan-1-one 
• 128883-50-1 6-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydro-3-pyridinecarboxamide 
• 86380-72-5 1-(4-Bromo-phenyl)-4-(4-chloro-benzoyl)-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 74918-89-1 2-(4-Chloro-phenyl)-4-(4-methoxy-phenyl)-6-phenyl-pyridine 
• 74767-47-8 [(1R,2S,3S)-2-Benzoyl-3-(4-methoxy-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 74767-47-8 [(1R,2R,3S)-2-Benzoyl-3-(4-methoxy-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 78743-77-8 (4-Chloro-phenyl)-[(1R,2S,3R)-2-(4-methoxy-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 78743-77-8 (4-Chloro-phenyl)-[(1R,2S,3S)-2-(4-methoxy-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 123033-12-5 [(1R,2R)-2-(4-Chloro-benzoyl)-3-(4-methoxy-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 123033-12-5 [(1R,2S,3S)-2-(4-Chloro-benzoyl)-3-(4-methoxy-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 78121-85-4 2-(4-Chloro-phenyl)-4-(4-methoxy-phenyl)-6-p-tolyl-pyridine 
• 103973-26-8 1-(4-chlorophenyl)-3-(4-methoxyphenyl)naphthalene 
• 107095-25-0 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydroisoxazole 

Relevant articles and documents

Synthesis, crystal growth, studies on vibrational spectroscopy and nonlinear optical properties of 4-methoxy-4′-chlorochalcone

Good quality organic non linear optical (NLO) crystals of 4-methoxy-4′-chlorochalcone (4MCC) have been grown by slow evaporation solution growth method. The grown crystals were investigated with various spectroscopy techniques such as the structural confi

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.