657-78-3

Basic information

• Product Name: 3-(TRIFLUOROMETHYL)FORMANILIDE
• Synonyms: 3-(TRIFLUOROMETHYL)FORMANILIDE;3'-TRIFLUOROMETHYLFORMANILIDE;TIMTEC-BB SBB008106;3-(Trifluoromethyl)phenylformamide;3’-trifluoromethyl-formanilid;alpha,alpha,alpha-trifluoro-m-formotoluidid;alpha,alpha,alpha-trifluoro-m-formotoluidide;Formamide, N-[3-(trifluoromethyl)phenyl]-
• CAS NO: 657-78-3
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.13
• EINECS: 211-520-4
• Mol File: 657-78-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(TRIFLUOROMETHYL)FORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TRIFLUOROMETHYL)FORMANILIDE(657-78-3)
• EPA Substance Registry System: 3-(TRIFLUOROMETHYL)FORMANILIDE(657-78-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 657-78-3(Hazardous Substances Data)

Usage

General Description

3-(trifluoromethyl)formanilide is an organic chemical compound with the formula C9H9F3NO. It is white to light orange in color and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3-(TRIFLUOROMETHYL)FORMANILIDE is also used as a building block in the production of various other chemicals and materials. It has a molecular weight of 215.17 g/mol and a melting point of 99-101°C. 3-(trifluoromethyl)formanilide is known for its strong electronegative properties due to the presence of a trifluoromethyl group, which makes it an important component in the development of new materials and technologies in the pharmaceutical and chemical industries.

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 124-38-9 carbon dioxide 
• 298-12-4 Glyoxilic acid 
• 107-31-3 Methyl formate 
• 77287-34-4 formamide 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 64-18-6 formic acid 

Downstream Products

• 1414349-59-9 N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide 
• 1414349-69-1 N-formyl-2-(thiophen-2-yl)-N-(3-(trifluoromethyl)phenyl)acetamide 
• 1311947-52-0 C₁₆H₉F₃N₂O₂ 
• 2164-17-2 fluometuron 
• 74702-19-5 C₆H₄(CF₃)N(CHO)SCFCl₂ 
• 175436-69-8 N-N-Diformyl-3-trifluoromethylaniline 
• 22507-54-6 3-(trifluoromethyl)phenyl isocyanide dichloride 

Relevant articles and documents

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Copper promoted aerobic oxidative c(sp3)-c(sp3) bond cleavage of n-(2-(pyridin-2-yl)-ethyl)anilines

A strategy of aerobic oxidative C(sp3)-C(sp3) bond cleavage of N-ethylaniline derivatives bearing azaarenes for the synthesis of N-aryl formamides has been developed. This approach was carried out smoothly with the CuI/TEMPO/air system to give N-aryl formamides in yields of 50-90%. With this methodology, a mutagenically active compound was constructed in 90% yield. Moreover, the reaction also provided a one-pot synthetic tool for accessing a promoter of hematopoietic stem cells by difunctionalization in 61% yield.

A capable cobalt nano-catalyst for the N-formylation of various amines and its biological activity studies

The Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) were modified with 1,10-phenanthroline-5,6-diol and the relevant Co complex (Fe3O4@Phendiol@Co) synthesized as a nano-magnetic heterogeneous catalyst to be used for the N-formylation of various amines at room temperature under solvent-free conditions. Also, in order to find the better concept of the catalyst role, the N-formylation reaction was carried out by the use of ultrasound irradiation in the absence of the Co nano-catalyst and the results were compared. The catalyst characterized by different methods such as the elemental analysis (CHN), ICP, FT-IR, XRD, EDX, SEM, TEM, TG-DTA, VSM and XPS. In addition, the antioxidant and the antibacterial activities of the Fe3O4@Phendiol@Co nano-catalyst and its Phendiol ligand were in vitro screened by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and disc diffusion methods. Results showed that they possess strong antioxidant activity (IC50; 0.182?±?0.006?mg/ml) and good antibacterial potential in comparison to standards.