65717-97-7

Basic information

• Product Name: N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID
• Synonyms: DISIDA;DISOFENIN;GLYCINE, N-[2-[[2,6-BIS(1-METHYLETHYL)PHENYL]AMINO]-2-OXOETHYL]-N-(CARBOXYMETHYL)-;N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID;N-(2,6-diisopropylphenyl-*carbamoylmethyl)-iminod;N-(2,6-DIISOPROPYLPHENYL-*CARBAMOYLMETHY L)-IMINODIA;DISIDA, Disofenin, N-[[(2,6-Diisopropylphenyl)carbamoyl]methyl]iminodiacetic acid;N-2(2,6-Diisopropylphenyl-carbamoylmethyl)iminodiacetic acid (Disofenin, DISIDA), 98 %
• CAS NO: 65717-97-7
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.41
• Product Categories: Chelating Agents, Ligands;Chelating Agents & Ligands;Building Blocks;C13 to C42+;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 65717-97-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 196-198° (Zmbova); mp 191-192.5° (Best); mp 166-175°
• Boiling Point: 567.2 ºC at 760 mmHg
• Flash Point: 296.8ºC
• Appearance: /
• Density: 1.228 g/cm3
• Vapor Pressure: 1.05E-13mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID(65717-97-7)
• EPA Substance Registry System: N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID(65717-97-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 65717-97-7(Hazardous Substances Data)

Usage

Description

N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID is a complex organic compound with a unique molecular structure that has potential applications in various fields, particularly in the pharmaceutical and medical industries.

Uses

Used in Pharmacological Studies:
N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID is used as a ligand in pharmacological studies for identifying molecular structures that can be targeted for the treatment of advanced melanoma.
Used in Synthesis of Derivatives:
N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID is used as a reactant in the synthesis of N-(2,6-diisopropylacetanilido)-iminodiacetic acid derivatives, which are further used for labeling and studying the potential of hepatobiliary imaging agents.
Used in Radiopharmaceutical Preparation:
N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID is used in the preparation of labeled radiopharmaceuticals using a borohydride exchange resin, which can be employed for various diagnostic and therapeutic applications.
Used in Medical Imaging:
N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID is used in the evaluation of radiopharmaceuticals for cholescintigraphy, a medical imaging technique used to assess the function of the gallbladder and bile ducts.
Overall, N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID is a versatile compound with potential applications in various industries, particularly in the development of new drugs, diagnostic tools, and imaging agents.

InChI:InChI=1/C18H26N2O5/c1-11(2)13-6-5-7-14(12(3)4)18(13)19-15(21)8-20(9-16(22)23)10-17(24)25/h5-7,11-12H,8-10H2,1-4H3,(H,19,21)(H,22,23)(H,24,25)

Synthetic route

nitrilotriacetic acid (139-13-9) + 2,6-diisopropylbenzenamine (24544-04-5) → N-(carboxymethyl)-N-<2-(2,6-diisopropylphenyl)amino>-2-oxoethylglycine (65717-97-7)

Conditions	Yield
With pyridine; acetic anhydride 1.) a) 50 deg C, 15 min, b.) 70 deg C, 2 h, 2.) 75 deg C, 4 h; Yield given. Multistep reaction;

sodium [99Tc]pertechnetate + N-(carboxymethyl)-N-<2-(2,6-diisopropylphenyl)amino>-2-oxoethylglycine (65717-97-7) → (99m)Tc-2,6-diisopropylacetanilidoiminodiacetic acid

Conditions	Yield
Stage #1: sodium [99Tc]pertechnetate for 0.5h; Stage #2: N-(carboxymethyl)-N-<2-(2,6-diisopropylphenyl)amino>-2-oxoethylglycine With tin(ll) chloride In water at 20℃; for 0.5h;

Upstream product

• 139-13-9 nitrilotriacetic acid 
• 24544-04-5 2,6-diisopropylbenzenamine 

Relevant articles and documents

N-(carboxymethyl)-N-[2-(2,6-diisopropyl-phenyl)amino]-2-oxoethylglycine and analogues: Synthesis and characterization

-