658-07-1

Basic information

• Product Name: 2,6-Difluoro-4-nitrophenol
• Synonyms: 2,6-Difluoro-4-nitrophenol;2,6-Difluoro-4-nitrophenol 98%;3,5-Difluoro-4-hydroxynitrobenzene;4-nitro-2,6-Difluorophenol
• CAS NO: 658-07-1
• Molecular Formula: C₆H₃F₂NO₃
• Molecular Weight: 175.09
• Mol File: 658-07-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 99.7-100.7°C
• Boiling Point: 254.5 °C at 760 mmHg
• Flash Point: 107.7 °C
• Appearance: /
• Density: 1.619 g/cm³
• Vapor Pressure: 0.0107mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.28±0.44(Predicted)
• CAS DataBase Reference: 2,6-Difluoro-4-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluoro-4-nitrophenol(658-07-1)
• EPA Substance Registry System: 2,6-Difluoro-4-nitrophenol(658-07-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 658-07-1(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline

InChI:InChI=1/C6H3F2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H

Upstream product

• 66684-58-0 3,4,5-trifluoronitrobenzene 
• 18063-03-1 2,6-difluorobenzamide 
• 5509-65-9 2,6-difluoroaniline 
• 28177-48-2 2,6-difluorophenol 
• 141-78-6 ethyl acetate 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 392-25-6 1,3-difluoro-2-methoxy-5-nitrobenzene 
• 3828-41-9 2-chloro-1,3-difluoro-5-nitrobenzene 
• 126058-97-7 2,6-di-fluoro-4-aminophenol 
• 363-47-3 3,5-difluoro-4-methoxyaniline 
• 220353-18-4 1,3-difluoro-4-iodo-2-methoxybenzene 
• 220353-20-8 2,4-difluoro-3-methoxy-benzonitrile 
• 717094-51-4 (2,4-difluoro-3-methoxyphenyl)methanamine 
• 220353-16-2 3,5-difluoro-2-iodo-4-methoxyaniline 
• 337520-54-4 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene 
• 1268490-17-0 1-(3,5-difluoro-4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 1268490-55-6 N-{4-[(6-chloro-4-pyrimidinyl)oxy]-3,5-difluorophenyl}-N'-[3-(trifluoromethyl)phenyl]urea 
• 1268490-54-5 N-(3,5-difluoro-4-hydroxyphenyl)-N'-[3-(trifluoromethyl)phenyl]urea 
• 847861-84-1 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene 

Relevant articles and documents

Novel HPK1 inhibitor as well as preparation method and application thereof

The present invention provides an HPK1 kinase inhibitor, the preparation thereof and use thereof. Specifically, the present invention provides a compound as represented by formula I. The definitions on groups are as stated in the description. The compound has excellent HPK1 inhibitory activity, and therefore can be used for preparing a pharmaceutical composition for treating cancer and other diseases related to HPK1 activity.

A aqueous phase preparation 2, 6 - [...] method

The invention relates to a green preparation 2, 6 - [...] synthetic method, to industrial product is 2, 6 - difluoro-benzamide as the starting material, passes through the aqueous phase Huffman degradation reaction, the aqueous phase diazotisations directly after the hydrolysis, direct concentrated nitric acid nitration, the iron powder reduces the aqueous phase, the aqueous phase with the aqueous phase to diazotization coupling reaction of phenol, after five step process for preparing aqueous phase reactions 2, 6 - [...] production process and corresponding various process conditions. The beneficial effect of the present invention is: select industrialized product 2, 6 - difluoro-benzamide as the raw material, raw materials are easy, low cost, through the aqueous phase reaction and solvent-free reaction for the preparation of 2, 6 - [...], its mild reaction conditions and environmental, safety and high efficiency. The present invention provides a kind of environmental protection, model, high efficiency can be used for the industrial production of 2, 6 - [...] green synthetic pathway.

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.