658-24-2

Basic information

• Product Name: AKOS 91597
• Synonyms: AKOS 91597;2,5-DIAZA-BICYCLO[2.2.2]OCTANE
• CAS NO: 658-24-2
• Molecular Formula: C₆H₁₂N₂
• Molecular Weight: 112.17
• Mol File: 658-24-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 196.3±8.0 °C(Predicted)
• Appearance: /
• Density: 0.975±0.06 g/cm3(Predicted)
• PKA: 10.76±0.20(Predicted)
• CAS DataBase Reference: AKOS 91597(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS 91597(658-24-2)
• EPA Substance Registry System: AKOS 91597(658-24-2)

Safety Data

• Hazardous Substances Data: 658-24-2(Hazardous Substances Data)

Usage

General Description

AKOS 91597 is a chemical compound with the molecular formula C27H33N, and a molecular weight of 371.56 g/mol. It is a derivative of pyrrolidine and amines. The compound is a light yellow powder with a melting point of 90-95°C. It is insoluble in water but soluble in organic solvents such as methanol and ethanol. AKOS 91597 is commonly used in pharmaceutical research and as an intermediate in organic synthesis. It is also known to have potential biological and pharmacological properties and is being studied for its various potential applications in the field of medicine and biotechnology.

Upstream product

• 54221-38-4 (2R,5S)-2,5-diazidohexanedioic acid diethyl ester 
• 54221-37-3 diethyl meso-2,5-dibromoadipate 
• 1004-98-4 2,5-diazabicyclo<2.2.2>octane-3,6-dione 

Downstream Products

• 1076206-57-9 2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.2]octane 
• 286943-65-5 2-(3-pyridinyl)-2,5-diazabicyclo[2.2.2]octane 

Relevant articles and documents

AUTOTAXIN INHIBITORS COMPRISING A HETEROAROMATIC RING-BENZYL-AMIDE-CYCLE CORE

The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Piperadinyl-substituted pyridylalkane, alkene and alkine carboxamides

The invention relates to new piperidinyl-substituted pyridyl carboxamides of the general formula (I), wherein the structure element E has meanings (E1) or (E2) and whereby the heterocyclic ring can optionally have a double bond. These substances have especially high cytostatic activities and pronounced immunosuppressive properties which make them suitable for therapeutic treatment in broad tumor spectrum.

Antifilarial agents. Diazabicyclooctanes and diazabicycloheptanes as bridged analogs of diethylcarbamazine

Twelve analogs of diethylcarbamazine (DEC) were prepared by acylation of 3 and 8 methyl 3,8 diazabicyclo[3.2.1]octane, 2 methyl 2,5 diazabicyclo[2.2.2]octane, and 2 methyl 2,5 diazabicyclo[2.2.1]heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from DEC in possessing two or one carbon bridges over the piperazine ring. When evaluated against Litomosoides carinii in the gerbil, all compounds strongly suppressed blood microfilaremia levels but did not affect the adult worms. Several compounds were nearly equivalent to DEC in activity. The results are discussed in terms of molecular model studies and receptor site theory.