658-89-9

Basic information

• Product Name: 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE
• Synonyms: 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE;4-(TRIFLUOROMETHOXY)-1,2-PHENYLENEDIAMINE;4-(TRIFLUOROMETHOXY)BENZENE-1,2-DIAMINE;4-(Trifluoromethoxy)benzene-1,2-diamine 97%;1,2-Diamino-4-(trifluoromethoxy)benzene, 4-(Trifluoromethoxy)phenylene-1,2-diamine;4-Trifluoromethoxy-1,2-diaminobenzene
• CAS NO: 658-89-9
• Molecular Formula: C₇H₇F₃N₂O
• Molecular Weight: 192.14
• Product Categories: Fluorine series
• Mol File: 658-89-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 249.7°C at 760 mmHg
• Flash Point: 104.8°C
• Appearance: /
• Density: 1.429g/cm³
• Vapor Pressure: 0.0226mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.30±0.10(Predicted)
• Stability: Air Sensitive
• CAS DataBase Reference: 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE(658-89-9)
• EPA Substance Registry System: 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE(658-89-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-43
• Safety Statements: 26-36/37/39-36/37
• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 658-89-9(Hazardous Substances Data)

Usage

Uses

1,?2-?Diamino-?4-?(trifluoromethoxy)?benzene is a useful synthetic compound.

InChI:InChI=1/C7H7F3N2O/c8-7(9,10)13-4-1-2-5(11)6(12)3-4/h1-3H,11-12H2

Upstream product

• 69695-61-0 2-chloro-4-(trifluoromethoxy)aniline 
• 175278-17-8 2-bromo-4-trifluoromethoxyaniline 
• 123-30-8 4-amino-phenol 
• 2267-22-3 2-nitro-5-(trifluoromethoxy)aniline 
• 787-57-5 2-nitro-4-trifluoromethoxy-N-acetylaniline 
• 1737-06-0 N-(4-(trifluoromethoxy)phenyl)acetamide 
• 461-82-5 4-(trifluoromethoxy)aniline 
• 1351534-05-8 2-amino-4-trifluoromethoxy-N-acetylaniline 
• 2267-23-4 2-nitro-4-trifluoromethoxyaniline 

Downstream Products

• 886465-13-0 1-(2-amino-4-trifluoromethoxy-phenyl)3-prop-2-ynyl-thiourea 
• 886465-12-9 1-(2-amino-5-trifluoromethoxy-phenyl)3-prop-2-ynyl-thiourea 
• 877681-12-4 5-(trifluoromethoxy)-1,3-dihydro-2H-benzo[d]imidazol-2-one 

Relevant articles and documents

SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

Synthesis method of 5-(trifluoromethoxy)-1H-benzo[d] imidazole-2-carboxylic acid

The invention belongs to the technical field of medical intermediates, and particularly relates to a synthesis method of 5-(trifluoromethoxy)-1H-benzo[d] imidazole-2-carboxylic acid. A compound A is used as an initial raw material, through the effect of i

HETEROCYCLIC ACETAMIDE COMPOUND

[Problem] A compound which is useful as a dopamine D1 receptor positive allosteric modulator (D1 PAM) is provided. [Means for Solution] The present inventors have studied a compound which has a dopamine D1 receptor positive allosteric modulating activity and is useful as an active ingredient of a pharmaceutical composition for preventing and/or treating cognitive impairment, negative symptoms of schizophrenia, Parkinson's disease, Alzheimer's disease, Huntington's disease, drug addictions, or the like, and they have thus found that a heterocyclic acetamide compound has a dopamine D1 receptor positive allosteric modulating activity, thereby completing the present invention. The heterocyclic acetamide compound of the present invention has a dopamine D1 receptor positive allosteric modulating activity and can be used as an agent for preventing and/or treating cognitive impairment, negative symptoms of schizophrenia, Parkinson's disease, Alzheimer's disease, Huntington's disease, drug addictions, or the like.