658066-44-5

Basic information

• Product Name: 2-(3-chloro-5-(trifluoroMethyl)pyridin-2-yl)ethanaMine
• Synonyms: 2-(3-chloro-5-(trifluoroMethyl)pyridin-2-yl)ethanaMine;2-(2-Aminoethyl)-3-chloro-5-(trifluoromethyl)pyridine;3-Chloro-5-(trifluoromethyl)-2-(2-aminoethyl)pyridine;2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]ethanamine
• CAS NO: 658066-44-5
• Molecular Formula: C₈H₈ClF₃N₂
• Molecular Weight: 224.6107296
• Mol File: 658066-44-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 230.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.364±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.20±0.10(Predicted)
• CAS DataBase Reference: 2-(3-chloro-5-(trifluoroMethyl)pyridin-2-yl)ethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chloro-5-(trifluoroMethyl)pyridin-2-yl)ethanaMine(658066-44-5)
• EPA Substance Registry System: 2-(3-chloro-5-(trifluoroMethyl)pyridin-2-yl)ethanaMine(658066-44-5)

Safety Data

• Hazardous Substances Data: 658066-44-5(Hazardous Substances Data)

Usage

General Description

2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine is a chemical compound with the formula C8H8ClF3N2. It is a derivative of pyridine, containing a trifluoromethyl group and a chlorine atom. The compound is used in pharmaceutical research and development, particularly in the study of neurological disorders and psychiatric conditions. It has been investigated for its potential as a central nervous system stimulant and has shown promise in preclinical studies. Additionally, it has potential applications as a building block in the synthesis of other pharmaceutical compounds and organic materials. The compound is typically handled and used with appropriate safety precautions due to its potential for irritation and toxicity.

Upstream product

• 923251-81-4 ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 172527-71-8 diethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)malonate 
• 157764-10-8 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile 

Downstream Products

• 659743-84-7 C₁₇H₁₄ClF₃N₂O₃ 

Relevant articles and documents

Design, synthesis biological activity, and docking of novel fluopyram derivatives containing guanidine group

Succinate dehydrogenase (SDH), a crucial bridge enzyme between the respiratory electron transfer chain and tricarboxylic acid (or Krebs) cycle, has been identified as an ideal target for the development of effective fungicide. In this study, a series of 24 novel SDH inhibitors (SDHIs) were designed, synthesized, and characterized by 1H NMR, 13C NMR, and HRMS. In vitro fungicidal activity experiments, most of the compounds exhibited broad-spectrum antifungal activities against five plant pathogenic fungi. Compounds 9j and 9k showed excellent activities against Pythium aphanidermatum with EC50 values of 9.93 mg/L and 10.50 mg/L, respectively, which were superior to the lead compound Fluopyram with an EC50 value of 19.10 mg/L. Furthermore, the toxicity of these compounds was also tested against Meloidogyne incognita J2 nematodes. The results indicated that compound 9x exhibited moderate nematicidal activity (LC50/48 h = 71.02 mg/L). Molecular docking showed that novel guanidine amide of 9j formed hydrogen bonds with crucial residues, which was crucial to the binding of an inhibitor and SDH. This present work indicates that these derivatives may serve as novel potential fungicides targeting SDH.

CATALYTIC HYDROGENATION OF NITRILES

The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [= Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [= Py-ethanamine] or salts thereof in the presence of Raney catalysts, in particular Raney nickel or cobalt.

Convenient routes to trifluoromethyl-substituted pyridyl-isothiocyanates and isocyanates starting from 2,3-dichloro-5-trifluoromethyl pyridine

A convenient preparative route for the synthesis of 3-chloro-2- (isothiocyanatoethyl)-5-(trifluoromethyl)pyridine (1) and 3-chloro-2- (isocyanatoethyl)-5-(trifluoromethyl)pyridine (2) has been developed, involving 5 steps starting from 2, 3-dichloro-5-(trifluoromethyl)pyridine (3). All intermediates and final products were obtained in good yields and purity. The structure of one intermediate, 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl) malonate, was confirmed by X-ray crystallography.