65861-49-6Relevant articles and documents
Preparation method of echinenone
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Paragraph 0044-0048; 0052-0056; 0060-0064; 0068-0080, (2020/05/14)
The invention discloses a preparation method of echinenone. According to the method, beta-apo-12 '-carotenal is oxidized into 4-oxo-beta-apo-12'-carotenal through regioselective oxidation, and then aC15 fragment is connected through a Witting reaction, so that the echinenone can be synthesized through a short-circuit line under the conditions of mild reaction conditions and simple process operation. The method has the advantages of short synthetic route, considerable product purity and yield, easily available raw materials, low cost, better industrial value, easiness in operation in the production process, no generation of toxic and harmful intermediates, and accordance with the concept of green and environment-friendly chemistry.
Synthese von optisch aktiven, natuerlichen Carotinoiden und strukturell verwandten Naturprodukten. IX. Synthese von (3R)-Hydroxyechinenon, (3R,3'R)- und (3R,3'S)-Adonixanthin, (3R)-Adonirubin, deren optischen Antipoden und verwandten Verbindungen
Bernhard, Kurt,Englert, Gerhard,Mayer, Hans,Mueller, Robert K.,Ruettimann, August,et al.
, p. 2469 - 2484 (2007/10/02)
The synthesis of racemic and optically active hydroxyechinenone (12-14), adonixanthin (16-19), adonirubin (22-24), meso-astaxanthin (26) and their corresponding diosphenols (15, 20, 21, 25, 27, 28, and 29) by Wittig reaction is reported, starting from suitable C15-phosphonium salts and C10-aldehydes.