658701-59-8 Usage
Description
6,10-Dihydroxy Buspirone is a compound that is formed as an impurity during the preparation of Buspirone metabolites. It is derived from Buspirone (B689855), which is a non-benzodiazepine anxiolytic and a 5-hydroxytryptamine (5-HT1) receptor agonist.
Uses
Used in Pharmaceutical Industry:
6,10-Dihydroxy Buspirone is used as an impurity in the preparation of Buspirone metabolites. It is formed during the synthesis process and may affect the purity and efficacy of the final product. Monitoring and controlling the levels of this impurity is important to ensure the quality and safety of Buspirone-based medications.
Used in Research and Development:
6,10-Dihydroxy Buspirone may also be used as a research compound to study its properties and potential effects. Understanding the role of this impurity in the synthesis of Buspirone metabolites can help in optimizing the production process and improving the overall quality of the final product. Additionally, research on 6,10-Dihydroxy Buspirone may provide insights into the development of new anxiolytic agents or other therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 658701-59-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,8,7,0 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 658701-59:
(8*6)+(7*5)+(6*8)+(5*7)+(4*0)+(3*1)+(2*5)+(1*9)=188
188 % 10 = 8
So 658701-59-8 is a valid CAS Registry Number.
658701-59-8Relevant articles and documents
Development of a safe and scalable oxidation process for the preparation of 6-hydroxybuspirone: Application of in-line monitoring for process ruggedness and product quality
Watson, Daniel J.,Dowdy, Eric D.,DePue, Jeffrey S.,Kotnis, Atul S.,Leung, Simon,O'Reilly, Brian C.
, p. 616 - 623 (2004)
The development of a safe and scalable oxidation process for the hydroxylation of the azapirone psychotropic agent buspirone (1) to furnish 6-hydroxybuspirone (2) is described. A mechanistic understanding of how key process factors affected product quality led to the successful application of FTIR as a process analytical technology (PAT) tool. This enabled real time quality assurance and the development of an effective and efficient manufacturing process. The identification of impurities and the development of recrystallization methods to provide active pharmaceutical ingredients (API) with optimal purity will also be addressed.
