65908-21-6Relevant articles and documents
Base-promoted annulation of amidoximes with alkynes: Simple access to 2,4-disubstituted imidazoles
Hua, Ruimao,Iqbal, Muhammad Asif,Lu, Le,Mehmood, Hina
, (2020/09/17)
An efficient construction of imidazole ring by a Cs2CO3-promoied annulation of amidoximes with terminal alkynes in DMSO has been developed. This protocol provides a simple synehetic ropte with high atom-utilieation for the synthesis of 2,4-disubstituted imidazoles in good yields under transition-metal-free and ligand-free conditions. Intornal alkynes can also undetgo the annulation to give 2,4,5-trisubstituted imidazoles.
ZnCl2-Catalyzed [3 + 2] Cycloaddition of Benzimidates and 2 H-Azirines for the Synthesis of Imidazoles
Shi, Shoujie,Xu, Kang,Jiang, Cheng,Ding, Zhenhua
, p. 14791 - 14796 (2018/11/23)
ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reactivity and high functional group tolerance.
Copper-Catalyzed Simultaneous Activation of C-H and N-H Bonds: Three-Component One-Pot Cascade Synthesis of Multi?-substituted Imidazoles
Pardeshi, Sachin D.,Sathe, Pratima A.,Vadagaonkar, Kamlesh S.,Melone, Lucio,Chaskar, Atul C.
, p. 361 - 370 (2018/01/12)
A copper-catalyzed expedient, practical, and straightforward approach for the one-pot three-component modular synthesis of multisubstituted imidazoles has been described by using arylacetic acids, N -arylbenzamidines, and nitroalkanes. The reaction involv
