65952-16-1Relevant articles and documents
X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors
Ivanova, Jekaterina,Leitans, Janis,Tanc, Muhammet,Kazaks, Andris,Zalubovskis, Raivis,Supuran, Claudiu T.,Tars, Kaspars
supporting information, p. 7108 - 7111 (2015/04/27)
1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly
Synthesis of 6-sulfamoylsaccharin and study of its reactivity in alkylation reactions
Ivanova,Simin, E. Yu.,Vozny,Trapencieris,?alubovskis
, p. 1561 - 1564 (2018/01/27)
An improved method for the preparation of 6-sulfamoylsaccharin (3-oxo-2,3-dihydro-1,2-benzothiazole-6-sulfonamide 1,1-dioxide) has been developed and studies of its possible direct alkylation have been carried out. It was shown that alkylation occursregio
