65961-01-5

Basic information

• Product Name: 7a-morpholin-4-yl-1-(4-nitro-phenyl)-1,3a,4,6,7,7a-hexahydro-thiopyrano[3,4-d][1,2,3]triazole
• CAS NO: 65961-01-5
• Molecular Weight: 349.414
• Mol File: 65961-01-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7a-morpholin-4-yl-1-(4-nitro-phenyl)-1,3a,4,6,7,7a-hexahydro-thiopyrano[3,4-d][1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7a-morpholin-4-yl-1-(4-nitro-phenyl)-1,3a,4,6,7,7a-hexahydro-thiopyrano[3,4-d][1,2,3]triazole(65961-01-5)
• EPA Substance Registry System: 7a-morpholin-4-yl-1-(4-nitro-phenyl)-1,3a,4,6,7,7a-hexahydro-thiopyrano[3,4-d][1,2,3]triazole(65961-01-5)

Safety Data

• Hazardous Substances Data: 65961-01-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 1072-72-6 Tetrahydrothiopyran-4-one 
• 1516-60-5 4-nitrophenyl azide 

Downstream Products

• 65961-11-7 1-(4-nitro-phenyl)-1,4,6,7-tetrahydro-thiopyrano[3,4-d][1,2,3]triazole 
• 65961-07-1 (2-methyl-thiophen-3-yl)-(4-nitro-phenyl)-amine 

Relevant articles and documents

v-Triazolines. Part 7. 3-Arylaminothiophens from hexahydrothiopyrano[3,4-d] -v-triazoles

By treating tetrahydrothiopyran-4-one with secondary amines and aryl azides. 1-aryl-7a-amino-1,3a,4,6,7,7a-hexahydrothiopyrano[3,4-d]-v-triazoles (2) were obtained. On heating with acids, compounds (2) afforded mixtures of the corresponding 3-arylamino-2-methylthiophen (3) and 1-aryl-1,4,6,7- tetrahydrothiopyrano[3,4-d]-v-triazole (4). The triazoles (4) were also obtained on heating compounds (2) with sodium hydroxide in methanol. 3,6-Dihydro-4-morpholino-2H-thiopyran (6) was treated with 4- nitrophenylsulphonyl azide yielding 4-morpholino-3-(4-nitrophenylsulphonylamino) -3,6-dihydro-2H-thiopyran (7). Reaction mechanisms are discussed.