659729-09-6

Basic information

• Product Name: 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine
• Synonyms: 4-Chloro-6-(4-(trifluoromethyl);PYRIMIDINE, 4-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]-
• CAS NO: 659729-09-6
• Molecular Formula: C₁₁H₆ClF₃N₂
• Molecular Weight: 258.63
• Mol File: 659729-09-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 318.736°C at 760 mmHg
• Flash Point: 146.567°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.61±0.18(Predicted)
• CAS DataBase Reference: 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine(659729-09-6)
• EPA Substance Registry System: 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine(659729-09-6)

Safety Data

• Hazardous Substances Data: 659729-09-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine is a chemical compound with the molecular formula C11H7ClF3N3. It is a pyrimidine derivative that contains a chlorine atom and a trifluoromethylphenyl group. 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It can also be used as a research tool in the study of biological processes and drug development. 4-Chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine is typically handled and stored under controlled conditions due to its potential reactivity and toxicity.

InChI:InChI=1/C11H6ClF3N2/c12-10-5-9(16-6-17-10)7-1-3-8(4-2-7)11(13,14)15/h1-6H

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 1590397-86-6 tert-butyl methyl(2-oxo-2-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methylamino)ethyl)carbamate 
• 1590397-87-7 2-(methylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide 
• 1590397-07-1 2-[(5-chlorothiophene-2-sulfonyl)(methyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 
• 1590397-08-2 2-[methyl-(thiophene-2-sulfonyl)-amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 
• 1590397-90-2 tert-butyl ethyl(2-oxo-2-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methylamino)ethyl)carbamate 
• 1590397-91-3 2-(ethylamino)-N-((6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)methyl)acetamide 
• 1590397-10-6 2-[ethyl-(4-fluorobenzenesulfonyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 
• 1590397-11-7 2-[(4-fluorobenzenesulfonyl)-(2-methoxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]-acetamide 
• 1590397-12-8 2-[(4-fluorobenzenesulfonyl)-(2-hydroxyethyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 
• 1590397-13-9 2-[tert-butyl-(4-fluorobenzenesulfonyl)-amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 
• 1590397-14-0 (S)-2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]propionamide 
• 1590397-20-8 (R)-2-[(4-fluorobenzenesulfonyl)(methyl)-amino]-N-[6-(4-trifluoromethylphenyl)-pyrimidin-4-ylmethyl]-propionamide 
• 1590397-31-1 2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide 
• 1257437-46-9 [6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]methylamine 

Relevant articles and documents

Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity

The synthesis of two series of novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities have been evaluated against three human tumour cell lines (HT-29, M21, and MCF7). In general, growth inhibition activity has been enhanced by the introduction of a bulky substituent on the aromatic ring with the best compound having GI50??6?μM for all the human tumour cell lines. The MCF7 selective compounds were evaluated on four additional human invasive breast ductal carcinoma cell lines (MDA-MB-231, MDA-MB-468, SKBR3, and T47D) and were selective against T47D cell line in all cases except one, suggesting a potential antiestrogen activity.

NOVEL HETEROCYCLIC COMPOUNDS AS ANTIMALARIAL AGENTS

The invention relates to novel heterocyclic compounds of the Formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the Formula I and

PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.