65976-63-8

Basic information

• Product Name: 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE
• Synonyms: 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE
• CAS NO: 65976-63-8
• Molecular Formula: C₁₀H₁₁ClN₂O₃
• Molecular Weight: 242.66
• Mol File: 65976-63-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 71-73°
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE(65976-63-8)
• EPA Substance Registry System: 4-(5-CHLORO-2-NITRO-PHENYL)-MORPHOLINE(65976-63-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65976-63-8(Hazardous Substances Data)

Usage

General Description

4-(5-chloro-2-nitro-phenyl)-morpholine is a chemical compound that consists of a morpholine ring substituted with a 5-chloro-2-nitro-phenyl group. It is commonly used in research and development as a building block for the synthesis of various pharmaceutical and agrochemical compounds. This chemical possesses potential pharmacological and biological activities due to its unique structure, making it a valuable intermediate for the production of new drugs and pesticides. However, it is important to handle this compound with care and adhere to safety guidelines due to its potential hazardous properties.

Upstream product

• 110-91-8 morpholine 
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• 65976-56-9 2,2'-(5-chloro-2-nitro-phenylazanediyl)-bis-ethanol 

Downstream Products

• 133387-34-5 4-[3-(morpholin-4-yl)-4-nitrophenyl]morpholine 
• 294649-44-8 4-[5-(4-Methyl-piperazin-1-yl)-2-nitro-phenyl]-morpholine 

Relevant articles and documents

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE

The invention relates to compounds of Formula (I), wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclooctane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.