65976-65-0

Basic information

• Product Name: 4-(3-chloro-4-nitrophenyl)morpholine
• Synonyms: 4-(3-chloro-4-nitrophenyl)morpholine
• CAS NO: 65976-65-0
• Molecular Weight: 242.662
• Mol File: 65976-65-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(3-chloro-4-nitrophenyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-chloro-4-nitrophenyl)morpholine(65976-65-0)
• EPA Substance Registry System: 4-(3-chloro-4-nitrophenyl)morpholine(65976-65-0)

Safety Data

• Hazardous Substances Data: 65976-65-0(Hazardous Substances Data)

Upstream product

• 65976-55-8 2,2'-(3-chloro-4-nitro-phenylazanediyl)-bis-ethanol 
• 109-02-4 4-methyl-morpholine 
• 611-06-3 2,4-dichloronitrobenzene 
• 110-91-8 morpholine 

Downstream Products

• 1610045-58-3 C₁₇H₂₁N₃O 

Relevant articles and documents

Nucleophilic Substitution Reaction of Aromatic Chlorides with Cyclic Tertiary Amines under High Pressure

The reaction of p-chloronitrobenzene with N-methylpyrrolidine under high pressure gave demethylation product and ring opening products through quaternary ammonium chloride intermediate formed by the SNAr reaction.On the other hand, the reactions with N-methylpiperidine and N-methylmorpholine gave only demethylation products.The reactions of o-chloronitrobenzene and 2,4-dichloronitrobenzene with above amines gave similar results.

Reaction of Mono-, Di-, and Trichloronitrobenzenes with N-Methyl Substituted Cyclic Tertiary Amines under High Pressure

The reactions of mono-, di-, and trichloronitrobenzenes with 1-methylpyrrolidine under high pressure gave products of demethylation and ring-opening through a quaternary pyrrolidinium chloride intermediate formed by the SNAr reaction.On the other hand, the reactions with 1-methylpiperidine and 4-methylmorpholine gave only demethylation products.The selectivities of the resctions of 1-methylpyrrolidine with these chloronitrobenzenes were found to be effected by the neighboring substituent to the pyrrolidinium group.