66-27-3 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 66-27-3 differently. You can refer to the following data:
1. colourless liquid
2. Clear, colorless to amber liquid.
Uses
Different sources of media describe the Uses of 66-27-3 differently. You can refer to the following data:
1. Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dan at 7-guanine, 3-guanine and 3-adenine.
2. Experimentally as mutagen, teratogen, brain carcinogen.
Definition
ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.
Air & Water Reactions
Water soluble.
Reactivity Profile
Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases.
Fire Hazard
Methyl methanesulfonate is combustible.
Safety Profile
Confirmed carcinogen
with carcinogenic and neoplastigenic data.
Poison by ingestion, intraperitoneal,
intravenous, and subcutaneous routes.
Human mutation data reported.
Experimental teratogenic and reproductive
effects. When heated to decomposition it
emits toxic fumes of SOx.
Potential Exposure
Research chemical and cancer drug.
No longer produced commercially in the United States.
Carcinogenicity
Methyl methanesulfonate is reascarcinogen based on sufficient evi
onably anticipated to be a human dence of carcinogenicity from studies in experimental animals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Purification Methods
Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.]
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Esters are generally
incompatible with nitrates. Moisture may cause hydrolysis
or other forms of decomposition
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by
flushing them down the toilet or discarding them to the
trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee
grounds, double-bagged in plastic, discard in trash.
Larger quantities shall carefully take into consideration
applicable DEA, EPA, and FDA regulations. If possible
return the pharmaceutical to the manufacturer for proper
disposal being careful to properly label and securely
package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported
by a state licensed medical waste contractor to dispose by
burial in a licensed hazardous or toxic waste landfill or
incinerator.
Check Digit Verification of cas no
The CAS Registry Mumber 66-27-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66-27:
(4*6)+(3*6)+(2*2)+(1*7)=53
53 % 10 = 3
So 66-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C2H6O3S/c1-5-6(2,3)4/h1-2H3
66-27-3Relevant articles and documents
King et al.
, p. 6304 (1971)
METHOD FOR THE PRODUCTION OF ALKANE SULFONIC ACID AT NON-SUPERACIDIC CONDITIONS
-
Page/Page column 12, (2020/10/09)
The present invention refers to a method for the production of alkane sulfonic acid, in which SO and an alkane are contacted with each other in the presence of a solvent, said solvent does not constitute a superacid and the combination of said solvent with one or more of the reactants also does not give rise to a superacid.
A highly active catalyst supported molecular sieves-NaHCO3 mixture for the selective and advantageous N-monoalkylation of amines
Das, Asish R.,Medda, Arunima,Singha, Raghunath,Guchhait, Nikhil
experimental part, p. 841 - 848 (2010/06/01)
Amines are mono-N-alkylated by alkylmesylates in the presence of catalyst supported molecular sieves-NaHCO3 mixture in a regioselective, chemoselective and non-toxic process. Observed chemoselectivity is supported by 'DFT'.
PREPARATION AND UTILITY OF SUBSTITUTED INDOLES
-
Page/Page column 34, (2008/06/13)
Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.
