660432-06-4Relevant articles and documents
Design of potent and selective 2-aminobenzimidazole-based p38α MAP kinase inhibitors with excellent in vivo efficacy
De Dios, Alfonso,Shih, Chuan,López De Uralde, Beatriz,Sánchez, Concepción,Del Prado, Miriam,Martín Cabrejas, Luisa M.,Pleite, Sehila,Blanco-Urgoiti, Jaime,Lorite, María José,Nevill Jr., C. Richard,Bonjouklian, Rosanne,York, Jeremy,Vieth, Michal,Wang, Yong,Magnus, Nicholas,Campbell, Robert M.,Anderson, Bryan D.,McCann, Denis J.,Giera, Deborah D.,Lee, Paul A.,Schultz, Richard M.,Li, Li C.,Johnson, Lea M.,Wolos, Jeffrey A.
, p. 2270 - 2273 (2007/10/03)
We report the design and discovery of a 2-amino-benzimidazole-based series of potent and highly selective p38α inhibitors. The lead compound 1 had low-nanomolar activity in both ATP competitive enzyme binding and inhibition of TNFα release in macrophages.
