66050-86-0

Basic information

• Product Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester
• Synonyms: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester
• CAS NO: 66050-86-0
• Molecular Weight: 352.353
• Mol File: 66050-86-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester(66050-86-0)
• EPA Substance Registry System: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester(66050-86-0)

Safety Data

• Hazardous Substances Data: 66050-86-0(Hazardous Substances Data)

Upstream product

• 1123-85-9 (RS)-2-phenyl-1-propanol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 37778-99-7 (S)-2-phenyl-1-propanol 
• 17257-71-5 (S)-Mosher acid 
• 492-37-5 hydratropic acid 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 

Relevant articles and documents

A molecular modelling approach to rationalize the stereochemical outcome of the Burkholderia cepacia lipase-catalyzed transesterification of aromatic primary alcohols with vinyl esters with different chain lengths in chloroform

The Burkholderia cepacia lipase-catalyzed transesterification of 2-methyl-3-phenyl-1-propanol with vinyl esters proceeds with high enantioselectivity independently of the acyl chain length and the low enantioselectivity of the same reaction with 2-phenyl-1-propanol is not affected by chain length of the vinyl esters. A molecular modelling approach has been developed in order to rationalize the enzymatic results.

Application of modified Mosher's method for primary alcohols with a methyl group at C2 position.

The absolute configurations of a series of primary alcohols possessing a branched methyl group at C2 position were examined on the basis of a modified Mosher's method proposed by Minale et al. It was revealed that in many cases the absolute configurations

MICROBIAL REDUCTION OF 2-PHENYLPROPIONIC ACID, 2-BENZYLOXYPROPIONIC ACID AND 2-(2-FURFURYL)PROPIONIC ACID

Racemic 2-phenylpropionic acid and 2-benzyloxypropionic acid were subjected to microbial reduction and simultaneous resolution with several molds. i. e., Malus and Prunus strains of Glomerella cingulata, Gloeosporium olivarum and Gloeosporium laeticolor, yielding (R)-2-phenylpropanol and (S)-2-benzyloxypropanol , and leaving (R)-2-phenylpropionic acid , respectively.The microbial reduction of racemic 2-(2-furfuryl)propionic acid gave optically inactive (+/-)-2-(2-furfuryl)propanol .Keywords- asymetric reduction; 2-benzyloxypropionic acid; 2-(2-furfuryl)prioionic acid; microbial reduction; microbial resolution; 2-phenylpropionic acid