66065-85-8 Usage
Description
N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE, also known as trichloroethoxycarbonyloxy succinimide, is a chemical compound with the molecular formula C9H8Cl3NO4. It is a derivative of succinimide, featuring a trichloroethoxycarbonyloxy group attached to the nitrogen atom. N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE is known for its reactivity and is commonly utilized in organic synthesis as an intermediate for the preparation of various pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Synthesis:
N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE is used as a synthetic intermediate for the preparation of complex organic molecules, particularly in the pharmaceutical industry. Its unique reactivity allows for the formation of diverse chemical structures, which can be further modified to create potential drug candidates.
Used in Organic Chemistry:
In the field of organic chemistry, N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE is used as a protecting group for amines. The trichloroethoxycarbonyloxy group can be selectively introduced and removed under mild conditions, making it a valuable tool for the synthesis of various organic compounds, including those with potential applications in materials science and chemical research.
Used in Synthesis of Specific Compounds:
N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE is used as a key intermediate in the synthesis of methyl [phenyl 5-(2,2,2-trichloroethoxycarbonylamino)-3,5-dideoxy-2-thio-β-D-glycero-D-galacto-2-nonulopyranosid]-onate and phenyl 3,4-di-O-benzyl-6-O-(tert-butyl-dimethyl-silyl)-1-selanyl-2-(2,2,2-trichloroethoxycarbonylamine)-β-D-galactopyranoside. These compounds have potential applications in the development of new drugs and pharmaceuticals, showcasing the versatility of N-(2,2,2-TRICHLOROETHOXYCARBONYLOXY)SUCCINIMIDE in organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 66065-85-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,0,6 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 66065-85:
(7*6)+(6*6)+(5*0)+(4*6)+(3*5)+(2*8)+(1*5)=138
138 % 10 = 8
So 66065-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H6Cl3NO5/c8-7(9,10)3-15-6(14)16-11-4(12)1-2-5(11)13/h1-3H2
66065-85-8Relevant articles and documents
Development of a facile method for polypeptide synthesis. Synthesis of bovine pancreatic trypsin inhibitor (BPTI)
Aimoto,Mizoguchi,Hojo,Yoshimura
, p. 524 - 531 (1989)
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Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxyamino acids using succinimidyl carbonates
Paquet, Alenka
, p. 976 - 980 (2007/10/02)
9-Fluorenylmethyl succinimidyl, pentachlorophenyl, and benzotriazole-1-yl carbonates were prepared and their reactivity with L-serine and L-serine benzyl ester was compared.The most efficient reagent, 9-fluorenylmethyl succinimidyl carbonate, was used for the preparation of 9-flourenylmethyloxycarbonyl derivatives of other hydroxyamino acids and hydroxyamino acid esters in high yields.The use of trichloroethyl and benzyl succinimidyl carbonates for an efficient conversion of hydroxyamino acids and their esters into the corresponding N-trichloroethoxycarbonyl and benzyloxycarbonyl derivatives is described.