660847-45-0

Basic information

• Product Name: Carbamic acid, [(1S)-1-[hydroxy(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-3-methylbutyl]-, 1,1-dimethylethyl ester
• CAS NO: 660847-45-0
• Molecular Formula: C19H27N3O4
• Molecular Weight: 361.441
• Mol File: 660847-45-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[hydroxy(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-3-methylbutyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[hydroxy(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-3-methylbutyl]-, 1,1-dimethylethyl ester(660847-45-0)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[hydroxy(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-3-methylbutyl]-, 1,1-dimethylethyl ester(660847-45-0)

Safety Data

• Hazardous Substances Data: 660847-45-0(Hazardous Substances Data)

Upstream product

• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 58521-45-2 tert-butoxycarbonyl-L-leucinal 

Downstream Products

• 660847-58-5 (1-{1(R/S)-[hydroxy-(5-phenyl-[1,3,4]oxadiazol-2-yl)-(S)-methyl]-3-methylbutylcarbamoyl}-2-(S)-methoxyethyl)carbamic acid tert-butyl ester 
• 660847-71-2 N₄-(2,2-dimethylpropyl)-N₁-(1-{1-(R/S)-[hydroxy-(5-phenyl-[1,3,4]oxadiazol-2-yl)-(S)-methyl]-3-(S)-methylbutylcarbamoyl}-2-methoxyethyl)-2(S)-(toluene-4-sulfonylamino)succinamide 

Relevant articles and documents

Optimization of subsite binding to the β5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors

Beginning with the peptide sequence Cbz-Ile-Glu(OtBu)-Ala-Leu found in PSI (3), a series of vinyl sulfones (VS) were synthesized for evaluation as inhibitors of the chymotrypsin-like activity of the 20S proteasome. Variations at the key P3 position confir