66145-80-0 Usage
Description
1-(2-deoxypentofuranosyl)-5-[(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione is a nucleoside derivative, characterized by its pentose sugar (2-deoxypentofuranosyl) and a pyrimidine nucleobase [(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione. 1-(2-deoxypentofuranosyl)-5-[(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione plays a significant role in biochemical research and pharmaceutical development.
Uses
Used in Biochemical Research:
1-(2-deoxypentofuranosyl)-5-[(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione is used as a precursor for the synthesis of modified nucleosides and nucleotides, which are crucial for studying the structure-activity relationships of nucleoside analogs. This application aids in drug development and design by providing valuable insights into the molecular interactions and mechanisms of action.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, 1-(2-deoxypentofuranosyl)-5-[(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione is utilized for the development of potential antiviral and anticancer agents. 1-(2-deoxypentofuranosyl)-5-[(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione's unique structure allows for the creation of modified nucleosides and nucleotides that can target specific viral and cancer-related pathways, offering new therapeutic options for patients.
Used in Drug Development:
1-(2-deoxypentofuranosyl)-5-[(hydroxyimino)methyl]pyrimidine-2,4(1H,3H)-dione is also employed in the development of novel drug delivery systems. By incorporating this compound into various organic and metallic nanoparticles, researchers aim to enhance the delivery, bioavailability, and therapeutic outcomes of modified nucleosides and nucleotides, ultimately improving the efficacy of antiviral and anticancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 66145-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,4 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 66145-80:
(7*6)+(6*6)+(5*1)+(4*4)+(3*5)+(2*8)+(1*0)=130
130 % 10 = 0
So 66145-80-0 is a valid CAS Registry Number.
66145-80-0Relevant articles and documents
Synthesis and antiviral activity of new 5-substituted 2′-deoxyuridine derivatives
Ivanov,Simonyan,Belanov,Aleksandrova
, p. 556 - 562 (2005)
New 5-azole- and 5-oxime-substituted analogues of 2′-deoxyuridine are synthesized. The analogues with azole ring manifest low toxicities and antiherpetic activities on Vero cell culture, the imidazole derivative being the most active. The inhibitory effects of oximes of 5-formyl-deoxyuridine are comparable with those of the azole-containing nucleoside analogues, although their cytotoxicities are found to be higher; oxime of 5-formyldeoxyuridine is particularly toxic. The nucleoside analogues synthesized exhibit no marked activity on cell cultures infected with various variants of poxvirus.
