66166-42-5

Basic information

• Product Name: 2-iodo-4-nitrophenyl phenyl ether
• Synonyms: 2-iodo-4-nitro-1-phenoxybenzene;2-iodo-4-nitrophenyl phenyl ether
• CAS NO: 66166-42-5
• Molecular Formula: C₁₂H₈INO₃
• Molecular Weight: 341.1
• Mol File: 66166-42-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-iodo-4-nitrophenyl phenyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-4-nitrophenyl phenyl ether(66166-42-5)
• EPA Substance Registry System: 2-iodo-4-nitrophenyl phenyl ether(66166-42-5)

Safety Data

• Hazardous Substances Data: 66166-42-5(Hazardous Substances Data)

Upstream product

• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 89487-91-2 2-iodo-4-nitrophenol 
• 100-02-7 4-nitro-phenol 
• 72212-81-8 2-hydroxy-5-nitrodiphenyliodonium ylide 
• 591-50-4 iodobenzene 
• 64-19-7 acetic acid 
• 75-15-0 carbon disulfide 
• 71-43-2 benzene 
• 66166-39-0 (2-hydroxy-5-nitro-phenyl)-phenyl-iodonium ; acetate 
• 5410-98-0 5-nitro-2-phenoxy-aniline 
• 177363-10-9 1-fluoro-2-iodo-4-nitrobenzene 

Downstream Products

• 20927-95-1 2-nitrodibenzofuran 
• 833-77-2 (2,4-diiodo-phenyl)-phenyl ether 
• 860735-00-8 3-iodo-4-phenoxy-aniline 

Relevant articles and documents

Metal-Free Synthesis of Etherified 3-(1H-1,2,3-Triazol-1-yl)phenyl Iodides through O–H Arylation/C–H Iodination with Diacetoxyiodobenzenes

A concise and efficient method for the synthesis of etherified 3-(1H-1,2,3-triazol-1-yl)phenyl iodides from 1,4-disubstituted 1,2,3-triazoles under metal-free conditions has been developed. In the presence of ArI(OAc)2, a range of 1,2,3-triazole substrates that contain a hydroxy group underwent a direct O–H arylation and C–H iodination to afford functionalized 1,2,3-triazoles in good to excellent yields.

Synthesis of medium-sized (6-7-6) ring compounds by iron-catalyzed dehydrogenative C-H activation/annulation

In this report, we have described a FeCl3-catalyzed process involving intramolecular annulation of o-phenoxy diarylacetylenes via hydroarylation to afford a series of biologically potent fused seven-membered (6-7-6) ring compounds under mild reaction conditions. This reaction was believed to proceed through Friedel-Crafts type sequential carbometallation followed by protonation to produce phenyldibenz[b,f]oxepines. This method was also extended to synthesize seven-membered rings that are fused with coumarins.

One-Pot Assembly of Fused Heterocycles via Oxidative Palladium-Catalyzed Cyclization of Arylols and Iodoarenes

A one-pot, two-step cyclization reaction of iodoarenes with diversified arylols, including 4-hydroxyquinoline, quinolinone, 4-hydroxypyridine and phenol, has been developed. By using this palladium-catalyzed formal tandem O-arylation, dehydrogenative cross-coupling reaction, a variety of biologically significant fused benzo[4,5]furo heterocycles and dibenzofurans were quickly assembled in high yields with excellent regioselectivity. Notably, the efficient one-pot reaction led to the heterocycles via sequential oxidation, iodination, isomerization and cyclization steps without purification of any reaction intermediates.