66179-55-3

Basic information

• Product Name: benzyloxycarbonylleucyl-hydroxamate
• Synonyms: benzyloxycarbonylleucyl-hydroxamate
• CAS NO: 66179-55-3
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.3196
• Mol File: 66179-55-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.178g/cm³
• Refractive Index: 1.535
• PKA: 9.44±0.40(Predicted)
• CAS DataBase Reference: benzyloxycarbonylleucyl-hydroxamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyloxycarbonylleucyl-hydroxamate(66179-55-3)
• EPA Substance Registry System: benzyloxycarbonylleucyl-hydroxamate(66179-55-3)

Safety Data

• Hazardous Substances Data: 66179-55-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H20N2O4/c1-10(2)8-12(13(17)16-19)15-14(18)20-9-11-6-4-3-5-7-11/h3-7,10,12,19H,8-9H2,1-2H3,(H,15,18)(H,16,17)/t12-/m0/s1

Upstream product

• 61-90-5 L-leucine 
• 51021-87-5 N-benzyloxycarbonyl-L-leucine methyl ester 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 30293-88-0 N-carbonyl-L-leucine methyl ester 
• 2018-66-8 N-carbobenzyloxy leucine 
• 66866-66-8 phenylmethyl (4S)-4-(2-methylpropyl)-5-oxo-1,3-oxazolidine-3-carboxylate 
• 2018-66-8 Z-Leu-OH 

Relevant articles and documents

A novel, simple and practical protocol for N - Protected - α - Amino hydroxamic acids

A facile single step methodology for the preparation of N-Protected-α- amino hydroxamic acids from readily accessible N-protected oxazolidinones using hydroxylamine hydrochloride and triethylamine is described.

Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin

Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields.