662111-65-1

Basic information

• Product Name: 2(1H)-Quinolinone, 5-[(1R)-1-hydroxy-2-[(phenylmethyl)amino]ethyl]-8-(phenylmethoxy)-
• CAS NO: 662111-65-1
• Molecular Formula: C25H24N2O3
• Molecular Weight: 400.477
• Mol File: 662111-65-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinolinone, 5-[(1R)-1-hydroxy-2-[(phenylmethyl)amino]ethyl]-8-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 5-[(1R)-1-hydroxy-2-[(phenylmethyl)amino]ethyl]-8-(phenylmethoxy)-(662111-65-1)
• EPA Substance Registry System: 2(1H)-Quinolinone, 5-[(1R)-1-hydroxy-2-[(phenylmethyl)amino]ethyl]-8-(phenylmethoxy)-(662111-65-1)

Safety Data

• Hazardous Substances Data: 662111-65-1(Hazardous Substances Data)

Upstream product

• 173140-90-4 (R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone 
• 100-46-9 benzylamine 
• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 
• 62978-73-8 5-acetyl-8-hydroxy-2(1H)-quinolinone 
• 15450-72-3 2-oxo-1,2-dihydroquinolin-8-yl acetate 
• 15450-76-7 8-Hydroxy-1H-quinolin-2-one 
• 530084-79-8 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one 

Downstream Products

• 686351-35-9 5-{(1R)-2-[[6-({4-[3-(cyclopentylsulfonyl)phenyl]butyl}oxy)hexyl](phenylmethyl)amino]-1-hydroxyethyl}-8-[(phenylmethyl)oxy]-2(1H)-quinolinone 

Relevant articles and documents

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

PHENETHANOLAMINE DERIVATIVE FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.