66217-29-6Relevant articles and documents
Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors
Congdon, Molly D.,Kharel, Yugesh,Brown, Anne M.,Lewis, Stephanie N.,Bevan, David R.,Lynch, Kevin R.,Santos, Webster L.
, p. 229 - 234 (2016)
The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation. SphKs are targets for various diseases such as cancer, fibrosis, and Alzheimer's and sickle cell disease. Herein, we disclose the structure-activity profile of naphthalene-containing SphK inhibitors and molecular modeling studies that reveal a key molecular switch that controls SphK selectivity.
SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS
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Page/Page column 233; 239, (2017/11/03)
Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides prodrugs of compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both, according to formula (I) as described herein. Formula I compounds are useful in the treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. The invention also provides pharmaceutical compositions of Formula I compounds.
Multichromophoric cyclodextrins. 4. Light conversion by antenna effect
Jullien, Ludovic,Canceill, Josette,Valeur, Bernard,Bardez, Elisabeth,Lefèvre, Jean-Pierre,Lehn, Jean-Marie,Marchi-Artzner, Valérie,Pansu, Robert
, p. 5432 - 5442 (2007/10/03)
A water soluble β-cyclodextrin (CD-NA) bearing seven naphthoyl chromophores forms very stable 1:1 complexes with a merocyanine laser dye DCM-OH (4-(dicyanomethylene)-2-methyl-6-(p-(bis(hydroxyethyl)amino)-styryl)-4 H-pyran). The antenna effect, i.e. energ
