663180-98-1

Basic information

• Product Name: methyl 3',5'-dibromo-[1,1'-biphenyl]-4-carboxylate
• Synonyms: methyl 3',5'-dibromo-[1,1'-biphenyl]-4-carboxylate
• CAS NO: 663180-98-1
• Molecular Weight: 370.04
• Mol File: 663180-98-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3',5'-dibromo-[1,1'-biphenyl]-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3',5'-dibromo-[1,1'-biphenyl]-4-carboxylate(663180-98-1)
• EPA Substance Registry System: methyl 3',5'-dibromo-[1,1'-biphenyl]-4-carboxylate(663180-98-1)

Safety Data

• Hazardous Substances Data: 663180-98-1(Hazardous Substances Data)

Upstream product

• 626-39-1 1,3,5-trisbromobenzene 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-44-3 methyl 4-iodobenzoate 
• 408492-26-2 2-(3,5-dibromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Two Principles of Reticular Chemistry Uncovered in a Metal-Organic Framework of Heterotritopic Linkers and Infinite Secondary Building Units

Structural diversity of metal-organic frameworks (MOFs) has been largely limited to linkers with at most two different types of coordinating groups. MOFs constructed from linkers with three or more nonidentical coordinating groups have not been explored. Here, we report a robust and porous crystalline MOF, Zn3(PBSP)2 or MOF-910, constructed from a novel linker PBSP (phenylyne-1-benzoate, 3-benzosemiquinonate, 5-oxidopyridine) bearing three distinct types of coordinative functionality. The MOF adopts a complex and previously unreported topology termed tto. Our study suggests that simple, symmetric linkers are not a necessity for formation of crystalline extended structures and that new, more complex topologies are attainable with irregular, heterotopic linkers. This work illustrates two principles of reticular chemistry: first, selectivity for helical over straight rod secondary building units (SBUs) is achievable with polyheterotopic linkers, and second, the pitch of the resulting helical SBUs may be fine-tuned based on the metrics of the polyheterotopic linker.

Prenylation inhibitors and methods of their synthesis and use

The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.