66346-91-6

Basic information

• Product Name: 3-Amino-6-morpholin-4-ylpyridazine
• Synonyms: 3-Amino-6-morpholin-4-ylpyridazine;3-AMino-6-Morpholinopyridazine, 97%;6-Morpholinopyridazin-3-aMine
• CAS NO: 66346-91-6
• Molecular Formula: C8H12N4O
• Molecular Weight: 180.20708
• Mol File: 66346-91-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 478.7°C at 760 mmHg
• Flash Point: 243.3°C
• Appearance: White to yellow/Crystalline Powder or Powder
• Density: 1.273g/cm³
• Vapor Pressure: 2.51E-09mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.66±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-6-morpholin-4-ylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-morpholin-4-ylpyridazine(66346-91-6)
• EPA Substance Registry System: 3-Amino-6-morpholin-4-ylpyridazine(66346-91-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 66346-91-6(Hazardous Substances Data)

Usage

General Description

3-Amino-6-morpholin-4-ylpyridazine is a chemical compound with the molecular formula C9H12N4O, and it is often used in pharmaceutical research and development. It has a pyridazine core structure with an amino group at the 3-position and a morpholine group at the 6-position. 3-Amino-6-morpholin-4-ylpyridazine has potential applications in medicinal chemistry, particularly in the development of new drugs for central nervous system disorders and other therapeutic areas. It is also being studied for its potential as an anticonvulsant and neuroprotective agent. Additionally, 3-Amino-6-morpholin-4-ylpyridazine has demonstrated interesting biological activities, making it a valuable tool for exploring new drug targets and mechanisms of action.

InChI:InChI=1/C8H12N4O/c9-7-1-2-8(11-10-7)12-3-5-13-6-4-12/h1-2H,3-6H2,(H2,9,10)

Upstream product

• 110-91-8 morpholine 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 187973-60-0 6-iodopyridazine-3-amine 

Relevant articles and documents

Preparation of differentially substituted 3,6-diaminopyridazines under mild conditions

Although desirable from a medicinal chemistry perspective, the differentially substituted 3,6-diaminopyridazine moiety is a highly challenging target using current literature approaches. Recent methods of Ullmann-type couplings are evaluated and a mild route to prepare these structures from iodide precursors is presented.

IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS

The present invention relates to substituted imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pΙ3Κβ inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates

Compounds useful as schistosomicidal agents are cyclic alkylidenyl N-[6-(R3 R4 N)-4(or 5)-R5 -3-pyridazinyl]aminomethylenemalonates (I), where R3 R4 N is lower-tertiary-amino and R5 is hydrogen or lower-alkyl, are prepared by reacting 3-amino-6-(R3 R4 N)-4(or 5)-R5 -pyridazine (III) with cyclic alkylidenyl α-(lower-alkoxymethylene)malonate (IV) or by heating equimolar quantities of III, tri-(lower-alkyl) orthoformate and cyclic alkylidenyl malonate (V). Also shown is cyclic isopropylidenyl N-(6-methylamino-3-pyridazinyl)aminomethylenemalonate, a schistosomicidal agent, and its preparation. Also shown are schistosomicidal compositions comprising as active component a schistosomicidally effective cyclic alkylidenyl N-[6-(R3 R4 N)-4(or 5)-R5 -3-pyridazinyl]aminomethylenemalonate (I) or cyclic isopropylidenyl N-(6-methylamino-3-pyridazinyl)aminomethylenemalonate (II) or salt thereof and a method for the treatment of schistosomiasis which comprises administering to a host infected with schistosomes a schistosomicidally effective amount of said active component.