66347-68-0 Usage
Description
Cyclohexane-1,2-diyldimethanediyl dimethanesulfonate, also known as Methylenebis(cyclohexylamine) dimethanesulfonate, is a chemical compound that serves as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is a bifunctional crosslinking agent known for its ability to enhance the mechanical properties and stability of polyurethane materials.
Uses
Used in Chemical Industry:
Cyclohexane-1,2-diyldimethanediyl dimethanesulfonate is used as a crosslinking agent for the production of polyurethane foams and elastomers, improving their mechanical properties and stability.
Used in Pharmaceutical Industry:
Cyclohexane-1,2-diyldimethanediyl dimethanesulfonate is used as a reagent in organic synthesis reactions, particularly in the formation of amine derivatives, contributing to the development of new pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 66347-68-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,3,4 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66347-68:
(7*6)+(6*6)+(5*3)+(4*4)+(3*7)+(2*6)+(1*8)=150
150 % 10 = 0
So 66347-68-0 is a valid CAS Registry Number.
66347-68-0Relevant articles and documents
Discovery of octahydroindenes as PAR1 antagonists
Lee, Sunkyung,Song, Jong-Hwan,Park, Chul Min,Kim, Jin-Seok,Jeong, Ji-Hye,Cho, Woo-Young,Lim, Dong-Chul
supporting information, p. 1054 - 1058 (2013/12/04)
Octahydroindene was identified as a novel scaffold for protease activated receptor 1 (PAR1) antagonists. Herein, the 2-position (C2) was explored for structure-activity relationship (SAR) studies. Compounds 14, 19, and 23b showed IC50 values of 1.3, 8.6, and 2.7 nM in a PAR1 radioligand binding assay, respectively, and their inhibitory activities on platelet activation were comparable to that of vorapaxar in a platelet rich plasma (PRP) aggregation assay. This series of compounds showed high potency and no significant cytotoxicity; however, the compounds were metabolically unstable in both human and rat liver microsomes. Current research efforts are focused on optimizing the compounds to improve metabolic stability and physicochemical properties as well as potency.