6635-76-3

Basic information

• Product Name: 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]thiourea
• CAS NO: 6635-76-3
• Molecular Formula: C₁₀H₈ClN₃S₂
• Molecular Weight: 269.7736
• Mol File: 6635-76-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 455.2°C at 760 mmHg
• Flash Point: 229.1°C
• Density: 1.519g/cm³
• Vapor Pressure: 1.79E-08mmHg at 25°C
• Refractive Index: 1.754
• CAS DataBase Reference: 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]thiourea(6635-76-3)
• EPA Substance Registry System: 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]thiourea(6635-76-3)

Safety Data

• Hazardous Substances Data: 6635-76-3(Hazardous Substances Data)

Usage

Type of compound

Thiourea derivative

Usage

Fungicide and herbicide

Function

Inhibits the growth of fungal and weed cells, preventing their spread and protecting crops

Classification

Pesticide

Safety

Relatively safe for use on crops with low toxicity to humans and animals when used as directed

Precaution

Proper handling and storage are essential to minimize potential risks

Upstream product

• 541-53-7 2,4-Dithiobiuret 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 2103-99-3 4-(4-chlorophenyl)-2-thiazolamine 
• 99-91-2 para-chloroacetophenone 
• 89012-11-3 N-(4-p-Chlorophenyl-2-thiazolyl)-N'-benzoylthiourea 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 7709-53-7 [4-(4-chloro-phenyl)-thiazol-2-yl]-cyanamide 
• 72752-94-4 2,7-bis-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-1,6-dithia-3,8-diaza-spiro[4.4]nona-2,7-diene-4,9-dione 
• 68666-18-2 [4-(4-chloro-phenyl)-thiazol-2-yl]-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-amine 
• 68666-13-7 [4-(2-chloro-5-methyl-phenyl)-thiazol-2-yl]-[4-(4-chloro-phenyl)-thiazol-2-yl]-amine 
• 68666-16-0 [4-(2-bromo-5-methyl-phenyl)-thiazol-2-yl]-[4-(4-chloro-phenyl)-thiazol-2-yl]-amine 
• 52471-10-0 2-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-thiazol-4-one 
• 52551-24-3 3-[4-(4-chloro-phenyl)-thiazol-2-yl]-2-thioxo-imidazolidin-4-one 
• 7713-85-1 bis-[4-(4-chloro-phenyl)-thiazol-2-yl]-amine 
• 52471-21-3 3-[4-(4-chloro-phenyl)-thiazol-2-yl]-5,5-diphenyl-2-thioxo-imidazolidin-4-one 
• 91092-13-6 1-[4-(4-chloro-phenyl)-thiazol-2-yl]-2-methyl-isothiourea 
• 68666-19-3 [4-(4-chloro-phenyl)-thiazol-2-yl]-[4-(2,5-dichloro-phenyl)-thiazol-2-yl]-amine 
• 89402-70-0 [2-[4-(4-Chloro-phenyl)-thiazol-2-ylamino]-4-(4-methoxy-phenyl)-thiazol-5-yl]-acetic acid 
• 89402-68-6 {2-[4-(4-Chloro-phenyl)-thiazol-2-ylamino]-4-phenyl-thiazol-5-yl}-acetic acid 
• 89402-69-7 {4-(4-Chloro-phenyl)-2-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-thiazol-5-yl}-acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of substituted thiazolamine, imidazo [2,1-b] thiazol-6(5H)-one, thiazolo [3,2-a] pyrimidin-5-one and thiazolyl thiourea derivatives

Substituted phenyl thiazole-2-amines (TA1-4) refluxed with ethyl acetoacetate using phosphorus oxychloride and polyphosphoric acid as a catalyst yielded thiazolo- pyrimidines (TP1-4) and with chloroacetic acid in ethanol furnished imizado- Thiazolos (IT1-4). Thiazolyl thioreas (TT1-4) were synthesized by the reaction of TA1-4 with ammonium thiocynate in dil hydrochloric acid. The structures of the synthesized compounds have been established on the basis of their spectral data and drug likelines was analyzed using Molinspiration online resource. The in vitro tuberculostatic potential evaluated against H37Rv strain of Mycobacterium tuberculosis by REMA assay has shown moderate activity for compound IT2. Synthesized compounds were screened against Staphylococcus aureus (MTCC 3160), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 40) and Pseudomonus aeruginosa (MTCC 424) bacteria and have shown significant activity.

Synthesis and characterization of some 3-N-alkoxyphthalimido-5-arylidene-2- {[4-(4-substituted phenyl)-1,3-thiazol-2-yl]imino}-1,3-thiazolidin-4-ones

4-Chloro/methyl phenacyl bromide 1a-b reacted with thiourea to furnish 2-amino thiazole 2a-b through Hantzsch's process, which were converted to their thiazolidinone derivatives 4a-b, by the reaction of corresponding thiazolyl thiourea 3a-b with chloroace

Synthesis and Antiinflammatory Activity of Some 5-Thiazoleacetic Acids

Four series of 5-thiazoleacetic acids (I, II, III and IV) have been synthesized for evaluation as potential antiinflammatory agents.Compounds of the series I, II and IV have been prepared by the condensation of various β-aroyl-β-bromopropionic acids (VIII