663619-90-7

Basic information

• Product Name: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-
• Synonyms: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-;9-bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;9-broMo-2-hydroxy-7-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one (Hydrochloride);9-Bromo-2-hydroxy-7-methyl-pyrido[1,2-a]pyrimidin-4-one
• CAS NO: 663619-90-7
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.07
• Product Categories: Drug Intermediates
• Mol File: 663619-90-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 377.1ºC at 760 mmHg
• Flash Point: 181.8ºC
• Appearance: /
• Density: 1.79
• Vapor Pressure: 3.13E-07mmHg at 25°C
• Refractive Index: 1.7
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-(663619-90-7)
• EPA Substance Registry System: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-(663619-90-7)

Safety Data

• Hazardous Substances Data: 663619-90-7(Hazardous Substances Data)

Usage

General Description

4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl- is a chemical compound with the molecular formula C10H8BrN3O2. It is a pyrido-pyrimidinone compound with a bromine atom and a hydroxyl group attached to a 7-methyl substituent. 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl- has potential biological activity and may be used in pharmaceutical research for the development of new drugs. It is important to handle this chemical with care and follow safety protocols when working with it in laboratory settings.

InChI:InChI=1/C9H7BrN2O2/c1-5-2-6(10)9-11-7(13)3-8(14)12(9)4-5/h2-4,13H,1H3

Upstream product

• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 
• 17282-00-7 3-bromo-5-methylpyridin-2-amine 

Downstream Products

• 351071-66-4 7-methyl-2-(4-morpholinyl)-9-{[(1R)-1-phenylethyl]amino}-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1657009-87-4 7-methyl-2-(4-methylpiperazin-1-yl)-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 351002-16-9 TGX₀₆₆ 
• 1374310-68-5 C₃₉H₅₈N₄O₄ 
• 1374310-69-6 C₂₉H₃₈N₄O₄ 
• 1173900-35-0 9-(1-hydroxyethyl)-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1307864-98-7 C₂₄H₂₈N₄O₄ 
• 1307865-00-4 NH₂-SL-TGX 
• 1307864-99-8 C₂₉H₃₉N₅O₄ 
• 1308384-65-7 TGX-D₁ 
• 663619-89-4 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one 
• 768401-13-4 MCA₅₂ 

Relevant articles and documents

Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling

A novel series of TGX-221 analogues was prepared and tested for their potency against the p110α, p110β, and p110δ isoforms of the PI3K enzyme, and in two cellular assays. The biological results were interpreted in terms of a p110β comparative model, in order to account for their selectivity towards this isoform. A CH2NH type linker is proposed to allow binding into the specificity pocket proposed to accommodate the high p110β-selectivity of TGX-221, although there was limited steric tolerance for substituents on the pendant ring with the 2-position most favourable for substitution.