6640-22-8 Usage
Description
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt is an organic compound with the chemical formula C22H14O6. It is a disodium salt of 4,4'-methylenebis(3-hydroxy-2-naphthoic acid), which is a type of naphthoic acid derivative. 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt has a molecular weight of 390.34 g/mol and is soluble in water.
Uses
Used in Pharmaceutical Industry:
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt is used as a modulator of drug release in various formulations. It is a potent agonist of the orphan receptor GPR35, which is a class A, rhodopsin-like G protein-coupled receptor (GPCR). Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain, and cancer.
Used in Inflammatory Conditions:
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt is used as an anti-inflammatory agent. It targets the GPR35 receptor, which is strongly expressed in immune cells, including monocytes and dendritic cells. By modulating the activity of these immune cells, it can help reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Pain Management:
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt is used as a pain-relieving agent. It targets the GPR35 receptor, which is expressed in dorsal root ganglia, a part of the nervous system involved in transmitting pain signals. By modulating the activity of GPR35, it can help reduce pain perception and provide relief from various types of pain.
Used in Cancer Therapy:
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt is used as a potential therapeutic agent in cancer treatment. Targeting the GPR35 receptor, which is expressed in various immune cells, can help modulate the immune response and enhance the body's ability to fight cancer cells. Additionally, it can be used in combination with other cancer therapies to improve treatment outcomes.
Flammability and Explosibility
Notclassified
Biological Activity
Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
Check Digit Verification of cas no
The CAS Registry Mumber 6640-22-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,4 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6640-22:
(6*6)+(5*6)+(4*4)+(3*0)+(2*2)+(1*2)=88
88 % 10 = 8
So 6640-22-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H16O6.2Na/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;;/h1-10,24-25H,11H2,(H,26,27)(H,28,29);;/q;2*+1/p-2
6640-22-8Relevant articles and documents
Stabilisation of pharmacologically active compounds in sustained release compositions
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, (2008/06/13)
A pharmaceutical composition comprising as the active agent a peptide in association with embonic acid or ascorbic acid or a salt thereof, excluding ψ ψ1) ACTH in association with embonic acid or acorbic acid or a salt thereof and ψ2) a LHRH active compound in association with ascorbic acid or a salt thereof,ψ in a matrix of a polylactide, having a lactide / glycolide molar ratio of from 100:0 to 40:60, a Mw of from 10.000 to 200.000 and a polydispersity of from 1.7 to 3.0. ψψ
