66419-08-7

Basic information

• Product Name: 14-Hydroxy-3β,2α-[[(2S,6R)-tetrahydro-3,5-dihydroxy-6-methyl-4-oxo-2H-pyran-2,3-diyl]bis(oxy)]-5α-card-20(22)-enolide
• Synonyms: 14-Hydroxy-3β,2α-[[(2S,6R)-tetrahydro-3,5-dihydroxy-6-methyl-4-oxo-2H-pyran-2,3-diyl]bis(oxy)]-5α-card-20(22)-enolide;Labriformidin
• CAS NO: 66419-08-7
• Molecular Formula: C29H36O11
• Molecular Weight: 532.6225
• Mol File: 66419-08-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 734°Cat760mmHg
• Flash Point: 241.7°C
• Appearance: /
• Density: 1.367g/cm³
• Vapor Pressure: 1.14E-30mmHg at 25°C
• Refractive Index: 1.648
• PKA: 9.59±0.70(Predicted)
• CAS DataBase Reference: 14-Hydroxy-3β,2α-[[(2S,6R)-tetrahydro-3,5-dihydroxy-6-methyl-4-oxo-2H-pyran-2,3-diyl]bis(oxy)]-5α-card-20(22)-enolide(CAS DataBase Reference)
• NIST Chemistry Reference: 14-Hydroxy-3β,2α-[[(2S,6R)-tetrahydro-3,5-dihydroxy-6-methyl-4-oxo-2H-pyran-2,3-diyl]bis(oxy)]-5α-card-20(22)-enolide(66419-08-7)
• EPA Substance Registry System: 14-Hydroxy-3β,2α-[[(2S,6R)-tetrahydro-3,5-dihydroxy-6-methyl-4-oxo-2H-pyran-2,3-diyl]bis(oxy)]-5α-card-20(22)-enolide(66419-08-7)

Safety Data

• Hazardous Substances Data: 66419-08-7(Hazardous Substances Data)

Usage

Classification

Cardiac glycoside medication

Source

Derived from the foxglove plant

Usage

Treats various heart conditions such as atrial fibrillation, atrial flutter, and heart failure

Mechanism of action

Increases the force of heart contractions and slows down the heart rate, improving the efficiency of the heart's pumping action

Administration

Typically administered orally or intravenously

Therapeutic window

Narrow, requiring careful dosing and monitoring

Potential toxicity

Must be used with caution and under the supervision of a healthcare professional

Historical use

Has been used for centuries for its cardiovascular effects

Molecular structure

Contains a complex arrangement of hydroxyl groups, carbonyl groups, and oxygen atoms in a cyclic structure

Stereochemistry

The molecule has specific stereochemistry at the 2S and 6R positions, which is important for its biological activity

Solubility

Generally more soluble in water than in nonpolar solvents due to the presence of multiple hydroxyl groups

Stability

Relatively stable under normal storage conditions, but should be protected from light and moisture

Metabolism

Metabolized in the liver and excreted primarily through the kidneys

Drug interactions

Can interact with various other medications, including other cardiovascular drugs, antibiotics, and herbal supplements

Side effects

Potential side effects include dizziness, confusion, nausea, vomiting, and visual disturbances, among others

Contraindications

Not recommended for use in certain conditions, such as secondor third-degree heart block, Wolff-Parkinson-White syndrome, or hypersensitivity to Digoxin or other cardiac glycosides.

InChI:InChI=1/C29H36O11/c1-12-6-18(30)29(35)24(37-12)38-16-8-14-9-19-28(40-19)22(25(14,2)10-17(16)39-29)21(32)23(33)26(3)15(4-5-27(26,28)34)13-7-20(31)36-11-13/h7,12,14-17,19,21-22,24,32,34-35H,4-6,8-11H2,1-3H3/t12-,14-,15-,16-,17-,19+,21+,22-,24+,25+,26+,27-,28+,29+/m1/s1