66424-92-8 Usage
Description
5-Methyl-2-nitrobenzyl alcohol is an organic compound that can be oxidized to form 5-methyl-2-nitrobenzaldehyde using various oxidizing agents and conditions. It is characterized by the presence of a methyl group and a nitro group attached to a benzyl alcohol structure.
Uses
Used in Chemical Synthesis:
5-Methyl-2-nitrobenzyl alcohol is used as a starting material for the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries. Its oxidation to 5-methyl-2-nitrobenzaldehyde is a key step in the production of these compounds.
Used in Pharmaceutical Industry:
5-Methyl-2-nitrobenzyl alcohol is used as an intermediate in the synthesis of pharmaceutical compounds. The oxidation product, 5-methyl-2-nitrobenzaldehyde, can be further modified to produce active pharmaceutical ingredients with potential therapeutic applications.
Used in Chemical Research:
5-Methyl-2-nitrobenzyl alcohol is used as a research compound for studying the effects of different oxidizing agents and conditions on the oxidation process. This helps in understanding the reactivity and selectivity of various oxidants and can lead to the development of more efficient and environmentally friendly synthetic methods.
Used in Material Science:
The oxidation products of 5-Methyl-2-nitrobenzyl alcohol, such as 5-methyl-2-nitrobenzaldehyde, can be used in the development of new materials with specific properties, such as dyes, pigments, or polymers, depending on the application requirements.
Check Digit Verification of cas no
The CAS Registry Mumber 66424-92-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,4,2 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66424-92:
(7*6)+(6*6)+(5*4)+(4*2)+(3*4)+(2*9)+(1*2)=138
138 % 10 = 8
So 66424-92-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3/c1-6-2-3-8(9(11)12)7(4-6)5-10/h2-4,10H,5H2,1H3
66424-92-8Relevant articles and documents
Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds
Ford, Russell L.,Alt, Isabel,Jana, Navendu,Driver, Tom G.
supporting information, p. 8827 - 8831 (2019/10/28)
A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.
JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE
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Page/Page column 75, (2014/10/04)
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): [FORMULA SHOULD BE INSERTED HERE] including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, z and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
SUBSTITUTED 1H-INDAZOL-1-OL ANALOGS AS INHIBITORS OF BETA CATENIN/TCF PROTEIN-PROTEIN INTERACTIONS
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Paragraph 00273, (2013/08/28)
In one aspect, the invention relates to substituted lH-benzo[d][l,2,3]triazol-l-ol analgoues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g. various tumors and cancers, associated with β-catenin/Tcf protein- protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
