664342-20-5Relevant articles and documents
Practical synthesis of ethyl 3-fluoro-1-pyrrole-2-carboxylate: A key fragment of a potent drug candidate against hepatitis b virus
René, Adeline,Quilan, Maxime,Deng, Yicheng,Cheng, Yang,Teleha, Christopher A.,Raboisson, Pierre,Bonfanti, Jean-Fran?ois,Fortin, Jér?me,Charette, André. B.,Pannecoucke, Xavier,Poisson, Thomas,Jubault, Philippe
, p. 792 - 801 (2019/10/16)
We report herein the development of two efficient synthetic routes for the preparation of a key fragment required for the synthesis of potent drug candidates of Hepatitis B virus. The ethyl 3-fluoro-1-H-pyrrole-2-carboxylate scaffold was synthesized from readily available starting materials in good overall yields. The scalability of one of the developed routes was demonstrated and afforded the desired target in good yield and excellent purity (99%).
A ring-closing metathesis pathway to fluorovinyl-containing nitrogen heterocyles
De Matteis, Valeria,Van Delft, Floris L.,Tiebes, Joerg,Rutjes, Floris P. J. T.
, p. 1166 - 1176 (2007/10/03)
The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring-closing metathesis reaction involving fluoride-substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
