66497-42-5

Basic information

• Product Name: 3-Hydroxy-6-methylpyridine-2-carboxaldehyde
• Synonyms: 3-Hydroxy-6-methylpyridine-2-carboxaldehyde;3-hydroxy-6-methyl-2-pyridinecarbaldehyde(SALTDATA: FREE);3-hydroxy-6-methylpicolinaldehyde;2-Pyridinecarboxaldehyde,3-hydroxy-6-methyl-
• CAS NO: 66497-42-5
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.136
• Mol File: 66497-42-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 106-107 °C
• Boiling Point: 283.596 °C at 760 mmHg
• Flash Point: 125.315 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.61
• PKA: 3.88±0.23(Predicted)
• CAS DataBase Reference: 3-Hydroxy-6-methylpyridine-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-6-methylpyridine-2-carboxaldehyde(66497-42-5)
• EPA Substance Registry System: 3-Hydroxy-6-methylpyridine-2-carboxaldehyde(66497-42-5)

Safety Data

• Hazardous Substances Data: 66497-42-5(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-6-methylpyridine-2-carboxaldehyde, also known as 6-methyl-3-pyridinecarboxaldehyde, is a chemical compound with the molecular formula C7H7NO2. It is a yellow solid with a strong, pungent odor and is soluble in water. 3-Hydroxy-6-methylpyridine-2-carboxaldehyde is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and imaging agents. It is also used in the production of flavoring and fragrance compounds. 3-Hydroxy-6-methylpyridine-2-carboxaldehyde has potential applications in the medical and agricultural industries due to its ability to act as a building block for more complex organic molecules. However, it is important to handle this chemical with caution, as it can be irritating to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H7NO2/c1-5-2-3-7(10)6(4-9)8-5/h2-4,10H,1H3

Upstream product

• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 50-00-0 formaldehyd 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 42097-42-7 3-hydroxy-2-hydroxymethyl-6-methylpyridine 

Downstream Products

• 1026251-92-2 6-Methyl-3-(4-phenyl-butoxy)-pyridine-2-carbaldehyde 
• 1026866-56-7 6-Methyl-3-(8-phenyl-octyloxy)-pyridine-2-carbaldehyde 
• 153748-36-8 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde 
• 141311-28-6 2-[5-Dodecyloxy-6-((E)-2-methoxycarbonyl-vinyl)-pyridin-2-ylmethylsulfanyl]-benzoic acid methyl ester 
• 141311-29-7 2-[5-Dodecyloxy-6-((E)-2-methoxycarbonyl-vinyl)-pyridin-2-ylmethanesulfinyl]-benzoic acid methyl ester 
• 141311-30-0 (E)-3-<<5-(dodecyloxy)-6-<2-(methoxycarbonyl)vinyl>pyridin-2-yl>methoxy>benzoic acid methyl ester 
• 141311-23-1 (E)-3-<<<5-(dodecyloxy)-6-<2-(methoxycarbonyl)vinyl>pyridin-2-yl>methyl>sulfanyl>benzoic acid methyl ester 
• 141311-26-4 4-[5-Dodecyloxy-6-((E)-2-methoxycarbonyl-vinyl)-pyridin-2-ylmethylsulfanyl]-benzoic acid methyl ester 
• 141311-25-3 (E)-3-<<<6-(2-carboxyvinyl)-5-(dodecyloxy)pyridin-2-yl>methyl>sulfonyl>benzoic acid methyl ester 
• 141311-08-2 (E)-3-{6-(3-Amino-phenylsulfanylmethyl)-3-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-yl}-acrylic acid methyl ester 
• 141311-31-1 (E)-3-<<5-(dodecyloxy)-6-<2-(methoxycarbonyl)vinyl>pyridin-2-yl>methoxy>benzoic acid methyl ester N-oxide 

Relevant articles and documents

Oxidation of 3-hydroxy-6-methyl-2-pyridinemethanol by chromium(VI) in acidic aqueous media; kinetic and EPR studies

Kinetics of oxidation of 3-hydroxy-6-methyl-2-pyridinemethanol (hmpol) by CrVI at HClO4 was studied under the pseudo-first-order conditions. The hmpol oxidation products were the appropriate aldehyde (hmpal) and acid (hmpac) coordinated to the chromium(III). The linear dependence of the pseudo-first-order rate constant (kobs) on [hmpol] at 1.0 and 2.0 M HClO4 and a parabolic dependence of kobs on [H+] were established. The apparent activation parameters were determined from the second-order rate constants at 1.0 M HClO4. The presence of the CrII and CrIV intermediates was deduced, based on rate retardation effect caused by O2 and MnII respectively, whereas the presence of CrV was established by EPR. Some correlations between the structure and stability of intermediate chromium(V) complexes have been discussed from EPR spectra, recorded during the redox process.

Pyridinium compounds

Methods for using novel quaternary pyridinium compounds in inhibiting acetylcholinesterase in mammals, specifically using the quaternary pyridinium compounds in the prophylaxis and treatment of organophosphate poisoning and mammalian dementia by mimicking or opposing the actions of the natural neurotransmitter acetylcholine.