66504-44-7

Basic information

• Product Name: 3-Azabicyclo[3.1.0]hexane-2,4-dione, 1-(3,4-dichlorophenyl)-
• CAS NO: 66504-44-7
• Molecular Formula: C11H7Cl2NO2
• Molecular Weight: 256.088
• Mol File: 66504-44-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Azabicyclo[3.1.0]hexane-2,4-dione, 1-(3,4-dichlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azabicyclo[3.1.0]hexane-2,4-dione, 1-(3,4-dichlorophenyl)-(66504-44-7)
• EPA Substance Registry System: 3-Azabicyclo[3.1.0]hexane-2,4-dione, 1-(3,4-dichlorophenyl)-(66504-44-7)

Safety Data

• Hazardous Substances Data: 66504-44-7(Hazardous Substances Data)

Upstream product

• 41204-08-4 ethyl α-bromo-3,4-dichlorophenylacetate 
• 6725-44-6 methyl 2-(3,4-dichlorophenyl)acetate 
• 163339-71-7 α-bromo-3,4-dichlorophenylacetic acid methyl ester 
• 877397-17-6 1-(3,4-dichlorophenyl)-1,2-cyclopropane-dicarboxylic acid dimethyl ester 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 344245-65-4 1-(3,4-dichlorophenyl)-1,2-cyclopropanedicarboxylic acid 
• 66504-42-5 (1R,2S)-1-(3,4-Dichloro-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 6725-45-7 ethyl 3,4-dichlorophenylacetate 
• 66504-43-6 (1R,2S)-1-(3,4-Dichloro-phenyl)-cyclopropane-1,2-dicarboxylic acid 

Downstream Products

• 923567-91-3 3-butyl-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione 
• 410074-74-7 Amitifadine hydrochloride 
• 86215-36-3 (+/-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0.]hexane hydrochloride 
• 410074-74-7 (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride 
• 66504-40-3 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane 

Relevant articles and documents

USE OF AMITIFADINE, (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN METHODS AND COMPOSITIONS WITH ENHANCED EFFICACY AND REDUCED METABOLIC SIDE EFFECTS AND TOXICITY FOR TREATMENT OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIO

The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azab

Novel polymorphs of azabicyclohexane

The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.

Method of treating depression using azabicyclohexanes

The present invention concerns certain novel substituted 3-azabicyclo[3.1.0]hexanes and a method of treating depression and stress in a warm-blooded animal, comprising the administration of substituted 3-azabicyclo[3.1.0]hexanes.