66545-20-8

Basic information

• Product Name: 4-((methyl(phenyl)amino)methyl)benzonitrile
• Synonyms: 4-((methyl(phenyl)amino)methyl)benzonitrile
• CAS NO: 66545-20-8
• Molecular Weight: 222.29
• Mol File: 66545-20-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-((methyl(phenyl)amino)methyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((methyl(phenyl)amino)methyl)benzonitrile(66545-20-8)
• EPA Substance Registry System: 4-((methyl(phenyl)amino)methyl)benzonitrile(66545-20-8)

Safety Data

• Hazardous Substances Data: 66545-20-8(Hazardous Substances Data)

Upstream product

• 623-26-7 terephthalonitrile 
• 93-90-3 N-(2-hydroxyethyl)-N-methylaminobenzene 
• 105-07-7 4-cyanobenzaldehyde 
• 100-61-8 N-methylaniline 
• 121-69-7 N,N-dimethyl-aniline 
• 7755-70-6 2-(methylamino)benzaldehyde 
• 17201-43-3 4-cyanobenzyl bromide 
• 36800-95-0 p-cyanophenyl p-toluenesulfonate 
• 767-00-0 4-cyanophenol 
• 93-61-8 N-methyl-N-phenylformamide 
• 874-86-2 4-cyanobenzyl chloride 

Relevant articles and documents

Thy Dynamics od α-Anilino Carboxylate and Related Cation Radical α-Heterolytic Fragmentations

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Tertiary amine alpha-position arylation method

The invention discloses a tertiary amine alpha-position arylation method, which comprises the following steps of: stirring tertiary amine and a cyanobenzene derivative which are used as raw materials in an organic solvent for a certain time by using inorg

Triarylamine-based porous coordination polymers performing both hydrogen atom transfer and photoredox catalysis for regioselective α-amino C(sp3)-H arylation

Direct functionalization of C(sp3)-H bonds in a predictable, selective and recyclable manner has become a central challenge in modern organic chemistry. Through incorporating different triarylamine-containing ligands into one coordination polymer, we present herein a heterogeneous approach to the combination of hydrogen atom transfer (HAT) and photoredox catalysis for regioselective C-H arylation of benzylamines. The different molecular sizes and coordination modes of the ligands, tricarboxytriphenylamine (H3TCA) and tris(4-(pyridinyl)phenyl)amine (NPy3), in one coordination polymer consolidate the triarylamine (Ar3N) moiety into a special structural intermediate, which enhances the chemical and thermal stability of the polymers and diminishes structural relaxation during the catalytic process. The inherent redox potentials of Ar3N moieties prohibit thein situformed Ar3N˙+to earn an electron from C(sp3)-H nucleophiles, but allow the abstraction of a hydrogen atom from C(sp3)-H nucleophiles, enabling the formation of the C(sp3)˙ radical and the cross-coupling reaction to proceed at the most electron-rich sites with excellent regioselectivity. The new heterogeneous photoredox HAT approach skips several interactions between transient species during the typical synergistic SET/HAT cycles, demonstrating a promising redox-economical and reagent-economical heterogeneous platform that has not been reported for α-amino C-H arylation to form benzylamine derivatives. Control experiments based on monoligand coordination polymers suggested that the mixed-ligand approach improved the photochemical and photophysical properties, providing important insight into rational design and optimization of recyclable photocatalysts for rapid access to complex bioactive molecules and late-stage functionalized pharmaceuticals.