66571-26-4

Basic information

• Product Name: 6-Methyl-1,2-benzisoxazol-3(2H)-one
• Synonyms: 6-Methyl-1,2-benzisoxazol-3(2H)-one;6-Methylbenzo[d]isoxazol-3(2H)-one;6-Methyl-1,2-benzoxazol-3-one;6-Methylbenzo[d]isoxazol-3(2H);6-Methyl-1,2-benzisoxazol-3-ol
• CAS NO: 66571-26-4
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Mol File: 66571-26-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 148-150 °C
• Boiling Point: 310.9 °C at 760 mmHg
• Flash Point: 141.8 °C
• Appearance: /
• Density: 1.259 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.66±0.20(Predicted)
• CAS DataBase Reference: 6-Methyl-1,2-benzisoxazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-1,2-benzisoxazol-3(2H)-one(66571-26-4)
• EPA Substance Registry System: 6-Methyl-1,2-benzisoxazol-3(2H)-one(66571-26-4)

Safety Data

• Hazardous Substances Data: 66571-26-4(Hazardous Substances Data)

Usage

General Description

6-Methyl-1,2-benzisoxazol-3(2H)-one, also known as MBO, is a chemical compound with the molecular formula C9H7NO2. It is a heterocyclic compound that contains a benzisoxazole ring with a methyl group attached. MBO is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential as an anticonvulsant and anti-inflammatory agent. The compound has been shown to possess antioxidant and antibacterial properties, making it a subject of interest for various research applications. Additionally, MBO has been identified as a potential environmental contaminant and has been studied for its impact on aquatic organisms.

Upstream product

• 4670-56-8 methyl 2-hydroxy-4-methylbenzoate 
• 50-85-1 2-hydroxy-p-toluic acid 
• 158671-29-5 N,2-dihydroxy-4-methylbenzamide 

Downstream Products

• 947408-94-8 6-methyl-2-triphenylmethyl-1,2-benzisoxazol-3(2H)-one 
• 16302-64-0 3-Chlor-6-methyl-1,2-benzisoxazol 

Relevant articles and documents

Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles

The Mitsunobu reaction has become one of the most powerful tools to alkylate acidic pronucleophiles. A significant caveat of Mitsunobu chemistry, however, is that the reaction mixture is often plagued with purification problems owing to the phosphine oxide and hydrazine dicarboxylate by-products. In addition to the development of more readily separable Mitsunobu reagents, the product's physicochemical properties may be exploited to facilitate purification. In this regard, we present a swift and efficient preparation of 3-hydroxybenzisoxazoles by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid–base work-up. As expected, a range of functional groups was compatible with the chemistry.

PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BEZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS

A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an opti

Benzo[d]isoxazol-3-ol DAAO inhibitors

Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutic amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein Z1 is N or CR3; Z2 is N or CR4; Z3is O or S; A is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc or a mixture thereof; R1, R2, R3 and R4 are independently selected from hydrogen, alkyl, hydroxy alkoxy, aryl, acyl, halo, cyano, haloalkyl, NHCOOR5 and SO2NH2; R5 is aryl, arylalkyl, heteroaryl or heteroarylalkyl; at least one of R1, R2, R3 and R4 is other than hydrogen; and at least one of Z1 and Z2 is other than N.