66574-84-3

Basic information

• Product Name: N-ACETYL-2-FLUORO-DL-PHENYLALANINE
• Synonyms: N-ACETYL-2-FLUORO-DL-PHENYLALANINE;N-ACETYL FLUOROPHENYLALANINE;ACETYL-DL-O-FLUOROPHENYLALANINE, N-;N-acetyl-2-fluoro-3-phenyl-DL-alanine;N-ACETYL-O-FLUORO-DL-PHENYL-ALANINECRYST ALLINE;N-Acetyl-2-Fluoro-Dl-Phenylalanine~99%;Ac-Phe(2-F)-OH;N-Acetyl-2-fluoro-DL-phenylalanine 98%
• CAS NO: 66574-84-3
• Molecular Formula: C₁₁H₁₂FNO₃
• Molecular Weight: 225.22
• EINECS: 266-409-3
• Product Categories: Amino Acids
• Mol File: 66574-84-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 153-155 °C(lit.)
• Boiling Point: 453.5 °C at 760 mmHg
• Flash Point: 228 °C
• Appearance: white to off-white powder
• Density: 1.2317 (estimate)
• Vapor Pressure: 5.17E-09mmHg at 25°C
• Storage Temp.: Keep Cold
• CAS DataBase Reference: N-ACETYL-2-FLUORO-DL-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-2-FLUORO-DL-PHENYLALANINE(66574-84-3)
• EPA Substance Registry System: N-ACETYL-2-FLUORO-DL-PHENYLALANINE(66574-84-3)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 66574-84-3(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white powder

InChI:InChI=1/C11H12FNO3/c1-7(14)13-10(11(15)16)6-8-4-2-3-5-9(8)12/h2-5,10H,6H2,1H3,(H,13,14)(H,15,16)/p-1/t10-/m1/s1

Upstream product

• 2629-55-2 2-fluoro-DL-phenylalanine 
• 108-24-7 acetic anhydride 
• 345-35-7 2-fluorobenzyl chloride 
• 380-69-8 acetylamino-(2-fluoro-benzyl)-malonic acid diethyl ester 

Downstream Products

• 97731-02-7 (R)-2'-fluorophenylalanine 
• 211811-93-7 N-Acetyl-2-fluoro-DL-phenylalanine 
• 19883-78-4 (S)-2-fluorophenylalanine 
• 69126-95-0 N-acetyl-2-fluoro-D-phenylalanine 
• 453-98-5 N-acetyl-2-fluoro-L-phenylalanine-(N'-phenyl-hydrazide) 
• 2629-55-2 2-fluoro-DL-phenylalanine 

Relevant articles and documents

Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light

A synthetic method that enables the Hantzsch ester-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) under blue LED (light emitting diode) light (456 nm) is described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21–99%. On introducing a chiral phosphoric acid, an asymmetric version of the reaction was also realised and provided product enantiomeric excess (ee) values of 53–99%. The reaction mechanism was delineated to involve excitation of an electron-donor acceptor (EDA) complex, formed from weak electrostatic interactions between the Hantzsch ester and NHPI, which generates the posited radical species of the redox active ester that undergoes addition to the N-heterocycle.