66584-72-3 Usage
Description
Ansamitocin P-3 is a macrocyclic antitumor antibiotic that is isolated from Actinosynnema pretiosum. It is a polyketide antibiotic that works by depolymerizing microtubules in both interphase and mitosis, and perturbs chromosome segregation.
Used in Pharmaceutical Industry:
Ansamitocin P-3 is used as an antitumor agent for its ability to depolymerize microtubules and perturb chromosome segregation, making it a potential candidate for cancer treatment.
Used in Cancer Research:
Ansamitocin P-3 is used as a research tool for studying the mechanisms of microtubule depolymerization and chromosome segregation in cancer cells, which can help in the development of new cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 66584-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,8 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66584-72:
(7*6)+(6*6)+(5*5)+(4*8)+(3*4)+(2*7)+(1*2)=163
163 % 10 = 3
So 66584-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10-
66584-72-3Relevant articles and documents
PREPARATION OF MAYTANSINOID ESTERS
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Paragraph 0444; 0445, (2014/07/08)
Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods.
Chemical modification of ansamitocins. II. Synthesis of 3-epimaytansionoids via 3-maytansinones
Akimoto,Kawai,Hashimoto,Nomura
, p. 2565 - 2570 (2007/10/02)
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