6659-45-6 Usage
General Description
1',2'-dihydrorotenone is a chemical compound that is a derivative of the natural product rotenone, which is a plant-derived insecticide and piscicide. It is a potent inhibitor of mitochondrial electron transport and has been studied for its potential as an anti-cancer agent. 1',2'-dihydrorotenone has also been investigated for its neuroprotective properties, as it has been shown to protect against the damage caused by oxidative stress and other neurotoxic insults. Additionally, research has suggested that this compound may have potential applications in the treatment of neurodegenerative diseases such as Parkinson's disease. Overall, 1',2'-dihydrorotenone is a versatile chemical with various potential uses in the fields of medicine and agriculture.
Check Digit Verification of cas no
The CAS Registry Mumber 6659-45-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,5 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6659-45:
(6*6)+(5*6)+(4*5)+(3*9)+(2*4)+(1*5)=126
126 % 10 = 6
So 6659-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C23H24O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,11,16,20-21H,8,10H2,1-4H3/t16-,20-,21+/m1/s1
6659-45-6Relevant articles and documents
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Haller,Schaffer
, p. 983 (1933)
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Cupples,Hornstein
, (1953)
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Hydromethylation of Unactivated Olefins
Dao, Hai T.,Li, Chao,Michaudel, Quentin,Maxwell, Brad D.,Baran, Phil S.
supporting information, p. 8046 - 8049 (2015/07/15)
A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly "edit" complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.
Synthesis of 3H labeled dihydrorotenone
O'Neil, James P.,VanBrocklin, Henry F.,Morimoto, Hiromi,Williams, Philip G.
, p. 215 - 221 (2007/10/03)
The catalytic tritiation of rotenone results in the preparation of two products, the expected tritiated 6',7'-dihydrorotenone ([3H]DHR) and tritiated 6',7'-dihydrorotenol ([3H]DHR-ol). The ratio of [3H]DHR to [3H]DHR-ol is 9 to 1. Reversed-phase HPLC provided the purified [3H]DHR and [3H]DHR-ol with estimated specific activities of 45 and 60 Ci/mmol, respectively.
