66625-56-7

Basic information

• Product Name: (E)-1-methyl-2-(phenylimino)indolin-3-one
• Synonyms: (E)-1-methyl-2-(phenylimino)indolin-3-one
• CAS NO: 66625-56-7
• Molecular Weight: 236.273
• Mol File: 66625-56-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-methyl-2-(phenylimino)indolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-methyl-2-(phenylimino)indolin-3-one(66625-56-7)
• EPA Substance Registry System: (E)-1-methyl-2-(phenylimino)indolin-3-one(66625-56-7)

Safety Data

• Hazardous Substances Data: 66625-56-7(Hazardous Substances Data)

Upstream product

• 1137-96-8 N-(benzylidene)aniline N-oxide 
• 62-53-3 aniline 
• 538-51-2 benzylidene phenylamine 
• 6411-55-8 2-phenylimino-indolin-3-one 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 52462-89-2 2-(N-methylformamido)-N-phenylbenzamide 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 62-53-3 aniline 

Relevant articles and documents

Syntheses of 2-Iminoindolin-3-ones and 2-Alknyl-2,3-dihydroquinazolin-4(1 H)-ones from 3-Diazoindolin-2-imines

3-Diazoindolin-2-imines reacted with nitrones to furnish 2-iminoindolin-3-ones through a Au(I)-catalyzed cascade oxygen transfer/imine exchange process. The prepared 2-iminoindolin-3-ones could be further transformed into 2-Alknyl-2,3-dihydroquinazolin-4(1H)-ones through a Ag(I)-catalyzed reaction with terminal alkynes. A MeOH-Triggered ring expansion mechanism involving cyclic iminium formation and nucleophilic addition is proposed for this novel alkynylation reaction. This two-step procedure provides a general and convenient approach to 2-Alknyl-2,3-dihydroquinazolin-4(1H)-ones, which are privileged structures in medicinal chemistry.