66659-65-2

Basic information

• Product Name: Ethanone, 1,2-bis(3-fluorophenyl)-2-hydroxy-
• CAS NO: 66659-65-2
• Molecular Formula: C14H10F2O2
• Molecular Weight: 248.229
• Mol File: 66659-65-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Ethanone, 1,2-bis(3-fluorophenyl)-2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1,2-bis(3-fluorophenyl)-2-hydroxy-(66659-65-2)
• EPA Substance Registry System: Ethanone, 1,2-bis(3-fluorophenyl)-2-hydroxy-(66659-65-2)

Safety Data

• Hazardous Substances Data: 66659-65-2(Hazardous Substances Data)

Upstream product

• 70028-89-6 1,2-bis(3-fluorophenyl)ethane-1,2-dione 
• 78-84-2 isobutyraldehyde 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 440118-79-6 2,3-bis(3-fluorophenyl)quinoxaline 
• 1349703-54-3 4,5-bis(3-fluorophenyl)-1H-imidazole 
• 1349703-47-4 1,3-diethyl-4,5-bis(3-fluorophenyl)-1H-imidazolium bromide 
• 1349703-53-2 1-ethyl-4,5-bis(3-fluorophenyl)-1H-imidazole 
• 1338828-77-5 2,3-bis(3-fluorophenyl)-1H-indole 
• 1338828-71-9 C₂₁H₁₅F₂NO 
• 66659-73-2 5,6-bis-(3-fluoro-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 
• 70028-89-6 1,2-bis(3-fluorophenyl)ethane-1,2-dione 
• 66659-69-6 4,5-Bis-(3-fluoro-phenyl)-1,3-dihydro-imidazole-2-thione 
• 143546-88-7 (3-{2-[4,5-Bis-(3-fluoro-phenyl)-oxazol-2-yl]-ethyl}-phenoxy)-acetic acid methyl ester 

Relevant articles and documents

Zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source

The zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source and zinc as reductant was successfully conducted. The presented method provides a low-cost, environmentally friendly and practical preparation of α-aryl amino esters, α-hydroxyketones and phenylethylenes. By using D2O as deuterium source, the corresponding products were obtained in high efficiency with excellent deuterium incorporation rate, which gives a cheap and safe tool for access to valuable deuterium-labelled compounds. This journal is

Base-Free Asymmetric Transfer Hydrogenation of 1,2-Di- and Monoketones Catalyzed by a (NH)2P2-Macrocyclic Iron(II) Hydride

The hydride isonitrile complex [FeH(CNCEt3)(1 a)]BF4 (2) containing a chiral P2(NH)2 macrocycle (1 a), in the presence of 2-propanol as hydrogen donor, catalyzes the base-free asymmetric transfer hydrogenation (ATH) of prostereogenic ketones to alcohols and the hemihydrogenation of benzils to benzoins, which contain a base-labile stereocenter. Benzoins are formed in up to 83 % isolated yield with enantioselectivity reaching 95 % ee. Ketones give the same enantioselectivity observed with the parent catalytic system [Fe(CNCEt3)2(1 a)] (3 a) that operates with added NaOtBu.

Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent α-glucosidase inhibitors

A new series of 1,2,4-triazine derivatives bearing carbazole moiety 7a-7p were designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. The majority of the screened compounds displayed potent α-glucosidase inhibitory activity, with IC50 values in the range of 4.27 ± 0.07-47.75 ± 0.25 μM as compared to the standard drug acarbose. Among the series, compound 7k represented the most potent α-glucosidase inhibitory activity with IC50 values of 4.27 ± 0.07 μM. Kinetic analysis revealed that compound 7k is a non-competitive inhibitor with a Ki of 4.43 μM. Furthermore, the binding interactions of compound 7k with α-glucosidase was confirmed through molecular docking. This study showed these 1,2,4-triazine derivatives bearing carbazole moiety as a new class of α-glucosidase inhibitors.