666725-78-6

Basic information

• Product Name: 4-Morpholinecarboxamide, N-[(1S)-2-[[(4S,7R)-hexahydro-7-methyl-3-oxo-1-(2-pyridinylcarbonyl)-1 H-azepin-4-yl]amino]-1-[(1-methylcyclohexyl)methyl]-2-oxoethyl]-
• CAS NO: 666725-78-6
• Molecular Formula: C28H41N5O5
• Molecular Weight: 527.664
• Mol File: 666725-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Morpholinecarboxamide, N-[(1S)-2-[[(4S,7R)-hexahydro-7-methyl-3-oxo-1-(2-pyridinylcarbonyl)-1 H-azepin-4-yl]amino]-1-[(1-methylcyclohexyl)methyl]-2-oxoethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinecarboxamide, N-[(1S)-2-[[(4S,7R)-hexahydro-7-methyl-3-oxo-1-(2-pyridinylcarbonyl)-1 H-azepin-4-yl]amino]-1-[(1-methylcyclohexyl)methyl]-2-oxoethyl]-(666725-78-6)
• EPA Substance Registry System: 4-Morpholinecarboxamide, N-[(1S)-2-[[(4S,7R)-hexahydro-7-methyl-3-oxo-1-(2-pyridinylcarbonyl)-1 H-azepin-4-yl]amino]-1-[(1-methylcyclohexyl)methyl]-2-oxoethyl]-(666725-78-6)

Safety Data

• Hazardous Substances Data: 666725-78-6(Hazardous Substances Data)

Upstream product

• 1318803-59-6 C₁₀H₁₈N₂ 
• 1318803-60-9 C₁₅H₂₇NO₄ 
• 1318803-62-1 C₂₇H₄₄N₄O₆S 
• 710942-17-9 1-methylcyclohexyl alanine 
• 41589-43-9 cyclohexylidene malonic acid diethyl ester 
• 79405-31-5 (1-methylcyclohexyl)acetaldehyde 
• 14352-58-0 (1-methylcyclohexyl)acetic acid 
• 82495-11-2 2-(1-methylcyclohexyl)ethanol 
• 78775-71-0 (1-methyl-cyclohexyl)-malonic acid 
• 108-94-1 cyclohexanone 
• 78775-64-1 (1-Methylcyclohexyl)malonsaeure-diethylester 

Relevant articles and documents

Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent

A series of azepanone inhibitors of cathepsin S is described. Selectivity over both cathepsin K and cathepsin L was achieved by varying the P2 substituent. Ultimately, a balanced potency and selectivity profile was achieved in compound 39 possessing a 1-methylcyclohexyl alanine at P2 and nicotinamide as the P′ substituent. The cellular potency of selected analogs is also described.