6668-56-0Relevant articles and documents
New insights into 4-anilinoquinazolines as inhibitors of cardiac troponin I-interacting kinase (TNNI3K)
Asquith, Christopher R. M.,Laitinen, Tuomo,Tizzard, Graham J.,Wells, Carrow I.,Zuercher, William J.
, (2020/04/17)
We report the synthesis of several related 4-anilinoquinazolines as inhibitors of cardiac troponin I-interacting kinase (TNNi3K). These close structural analogs of 3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide (GSK11
Dihydropteridinone-sulfamide derivatives, pharmaceutically-acceptable salts of derivatives, preparation method of derivatives and application of derivatives and salts
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Paragraph 0059-0061, (2019/10/29)
The invention provides dihydropteridinone-sulfamide derivatives as well as a preparation method and application thereof aiming at problems in the prior art, and provides a novel choice for developmentof an antitumor drug for inhibiting a bromodomain (BRD4
Amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide
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Paragraph 0017, (2017/08/29)
An amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide is disclosed. According to the method, 4-halogeno-benzenesulfonyl chloride which is used as a raw material undergoes nitration to prepare 3-nitro-4-halogeno-benzenesulfonyl chloride; and after aminolysis, 3-nitro-4-halogeno-benzenesulfonamide is prepared. By the synthesis method provided by the invention, the synthesis route by the adoption of chlorosulfonic acid is changed, and production safety is remarkably raised. The reaction condition is milder and is easy for production control. Thus, mass production of the compound is easier to implement and realize.