666844-61-7

Basic information

• Product Name: 3N-Benzyloxycarbonyl 3-Amino-2,2-dimethylpropanamide
• Synonyms: 3N-Benzyloxycarbonyl 3-Amino-2,2-dimethylpropanamide;(3-AMino-2,2-diMethyl-3-oxopropyl)carbaMic Acid PhenylMethyl Ester;3-[(Benzyloxycarbonyl)aMino]-2,2-di(Methyl)propionaMide;N-(3-AMino-2,2-diMethyl-3-oxopropyl)carbaMic Acid Benzyl Ester
• CAS NO: 666844-61-7
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.29362
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 666844-61-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate, Methanol
• CAS DataBase Reference: 3N-Benzyloxycarbonyl 3-Amino-2,2-dimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3N-Benzyloxycarbonyl 3-Amino-2,2-dimethylpropanamide(666844-61-7)
• EPA Substance Registry System: 3N-Benzyloxycarbonyl 3-Amino-2,2-dimethylpropanamide(666844-61-7)

Safety Data

• Hazardous Substances Data: 666844-61-7(Hazardous Substances Data)

Usage

Uses

Intermediate in the synthesis of Aliskiren.

Upstream product

• 7505-93-3 2-cyano-2-methylpropanamide 
• 501-53-1 benzyl chloroformate 
• 173336-49-7 3-benzyloxycarbonylamino-2,2-dimethylpropionic acid ethyl ester 
• 80253-36-7 3-(benzyloxycarbonylamino)-2,2-dimethylpropanoic acid 

Downstream Products

• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 324763-51-1 aminopivalinamide 

Relevant articles and documents

CYCLIC AMINE COMPOUND

The present invention provides an excellent antihypertensive medicament. The medicament of the present invention comprises a compound having the general formula (I) and the like: [wherein R1: H, substitutable alkyl, substitutable alkenyl, substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; R2: H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R3, R4; H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R5, R6: H, substitutable alkyl, substitutable cycloalkyl, substitutable alkoxy or the like; R7, R8: H, substitutable alkyl, substitutable cycloalkyl or the like; X: the formula (II) or the like; A: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; Y: a single bond, substitutable alkylene, substitutable alkenylene, -(CH2)a-X1-(CH2)b- (X1: the formula -NH-, -O- or the like; a, b: 0-5) or the like; B: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like].

Practical synthesis of an orally active renin inhibitor aliskiren

A convergent synthesis of aliskiren was accomplished via the use of Segment AB as the key intermediate, which was prepared via the coupling of the Grignard reagent derived from Segment B with Segment A, followed by subsequent oxidative lactonization.