666859-55-8

Basic information

• Product Name: 1,2,4-Oxadiazol-5(2H)-one, 3-(2-amino-5-bromophenyl)-
• CAS NO: 666859-55-8
• Molecular Formula: C8H6BrN3O2
• Molecular Weight: 256.059
• Mol File: 666859-55-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazol-5(2H)-one, 3-(2-amino-5-bromophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazol-5(2H)-one, 3-(2-amino-5-bromophenyl)-(666859-55-8)
• EPA Substance Registry System: 1,2,4-Oxadiazol-5(2H)-one, 3-(2-amino-5-bromophenyl)-(666859-55-8)

Safety Data

• Hazardous Substances Data: 666859-55-8(Hazardous Substances Data)

Upstream product

• 39263-32-6 2-amino-5-bromobenzonitrile 
• 666859-54-7 C₇H₈BrN₃O 
• 105-58-8 Diethyl carbonate 
• 1885-29-6 anthranilic acid nitrile 
• 666859-54-7 2-amino-5-bromo-N-hydroxybenzene-1-carboximidamide 

Downstream Products

• 666859-02-5 N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2,4-oxadiazol-3-yl) PHENYL]-3-phenoxybenzamide 
• 666858-74-8 3-(BENZYLTHIO)-N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2,4-oxadiazol-3-yl) phenyl] benzamide 
• 666859-32-1 N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2,4-oxadiazol-3-yl) PHENYL]-6-(isopropylthio) nicotinamide 
• 666858-72-6 N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2,4-oxadiazol-3-yl) PHENYL]-3-[ (5-chloro-2, 3-DIHYDRO-1H-INDOL-1-YL) sulfonyl] benzamide 
• 666859-00-3 N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2,4-oxadiazol-3-yl) PHENYL]-3-isopropoxybenzamide 
• 666859-30-9 N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2,4-oxadiazol-3-yl) PHENYL]-5-PHENYLISOXAZOLE-3-CARBOXAMIDE 
• 666858-88-4 N-[4-bromo-2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]-3-{[(4-chlorophenyl)(methyl)amino]sulfonyl}benzamide 
• 666858-84-0 N-[4-BROMO-2-(5-OXO-4, 5-DIHYDRO-1, 2, 4-OXADIAZOL-3-YL) phenyl]-4-(2, 3-DIHYDRO-1H-INDOL-1-YLSULFONYL) BENZAMIDE 

Relevant articles and documents

ARYLCARBOXAMIDES AND USES THEREOF

The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic diseases such as scleroderma; lung disease, such as pulmonary fibrosis including idiopathic pulmonary fibrosis (IPF); heart disease, such as heart failure due to ischaemic heart disease, valvular heart disease and hypertensive heart disease, diabetic cardiomyopathy and hypertension; liver disease, such as cirrhosis of the liver; and kidney disease, such as progressive kidney disease glomerulonephritis and diabetic nephropathy; and eye disease such as diabetic retinopathy; skin or subcutaneous scarring, such as keloids, adhesions, hypertrophic scarring or cosmetic scarring; or as an adjuvant or anti-fibrotic in pancreatic cancer to increase chemotherapeutic drug penetration by reducing the density of the connective tissue stroma.

ANTIBACTERIAL BENZOIC ACID DERIVATIVES

The present invention relates to antibacterial agents that are useful for sterilization, sanitation, antisepsis, disinfection, and treatment of antibacterial infections in mammals.