66692-98-6

Basic information

• Product Name: Isoxazole, 5-(4-chlorophenyl)-4-nitro-3-phenyl-
• CAS NO: 66692-98-6
• Molecular Formula: C15H9ClN2O3
• Molecular Weight: 300.701
• Mol File: 66692-98-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Isoxazole, 5-(4-chlorophenyl)-4-nitro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 5-(4-chlorophenyl)-4-nitro-3-phenyl-(66692-98-6)
• EPA Substance Registry System: Isoxazole, 5-(4-chlorophenyl)-4-nitro-3-phenyl-(66692-98-6)

Safety Data

• Hazardous Substances Data: 66692-98-6(Hazardous Substances Data)

Upstream product

• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 614-21-1 2-nitroacetophenone 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 873-67-6 benzonitrile oxide 
• 96751-46-1 trans-3-phenyl-4-nitro-5-(p-chlorophenyl)-4,5-dihydro-1,2-oxazole 
• 96751-46-1 cis-3-phenyl-5-(p-chlorophenyl)-4-nitro-2-isoxazoline 
• 66954-42-5 1-(4-chloro-phenyl)-2-nitro-3-phenyl-propane-1,3-dione 3-oxime 

Relevant articles and documents

Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines

It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.

SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. PART XVIII. A NEW, CONVENIENT METHOD FOR THE DEHYDROGENATION OF 3,5-DIARYL-4-NITRO-4,5-DIHYDRO-1,2-OXAZOLES

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SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. 10. SYNTHESIS OF 3,5-DIARYL-4-NITROISOXAZOLES

A method was proposed for the synthesis of 3,5-diaryl-4-nitroisoxazoles entailing the bromination of potassium salts of the corresponding 3,5-diaryl-Δ2-isoxazolinyl-4-nitronic acids.The method may be used for the conversions of both the trans and cis isomers of 3,5-disubstituted 4-nitro-Δ2-isoxazolines.