66702-71-4

Basic information

• Product Name: Benzenemethanol, a-[2-(3-pyridinyl)ethenyl]-, (E)-
• CAS NO: 66702-71-4
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Mol File: 66702-71-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-[2-(3-pyridinyl)ethenyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-[2-(3-pyridinyl)ethenyl]-, (E)-(66702-71-4)
• EPA Substance Registry System: Benzenemethanol, a-[2-(3-pyridinyl)ethenyl]-, (E)-(66702-71-4)

Safety Data

• Hazardous Substances Data: 66702-71-4(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 4452-13-5 1-phenyl-3-(pyridin-3-yl)prop-2-en-1-one 
• 500-22-1 3-pyridinecarboxaldehyde 

Relevant articles and documents

Potassium Base-Catalyzed Michael Additions of Allylic Alcohols to α,β-Unsaturated Amides: Scope and Mechanistic Insights

We report herein the first KHMDS-catalyzed Michael additions of allylic alcohols to α,β-unsaturated amides through allylic isomerization. The reaction proceeds smoothly in the presence of only 5 mol% of KHMDS to afford a variety of 1,5-ketoamides in high yields. Mechanistic investigations, including experimental and computational studies, reveal that the KHMDS-catalyzed in-situ generation of the enolate from the allylic alcohol through a tunneling-assisted 1,2-hydride shift is the key to the success of this transformation. (Figure presented.).